Publication: Stevioside and related compounds: Therapeutic benefits beyond sweetness
Issued Date
2009-01-01
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ISSN
01637258
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2-s2.0-57749106147
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Mahidol University
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SCOPUS
Bibliographic Citation
Pharmacology and Therapeutics. Vol.121, No.1 (2009), 41-54
Suggested Citation
Varanuj Chatsudthipong, Chatchai Muanprasat Stevioside and related compounds: Therapeutic benefits beyond sweetness. Pharmacology and Therapeutics. Vol.121, No.1 (2009), 41-54. doi:10.1016/j.pharmthera.2008.09.007 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28223
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Title
Stevioside and related compounds: Therapeutic benefits beyond sweetness
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Abstract
Stevioside, an abundant component of Stevia rebaudiana leaf, has become well-known for its intense sweetness (250-300 times sweeter than sucrose) and is used as a non-caloric sweetener in several countries. A number of studies have suggested that, beside sweetness, stevioside along with related compounds, which include rebaudioside A (second most abundant component of S. rebaudiana leaf), steviol and isosteviol (metabolic components of stevioside) may also offer therapeutic benefits, as they have anti-hyperglycemic, anti-hypertensive, anti-inflammatory, anti-tumor, anti-diarrheal, diuretic, and immunomodulatory actions. It is of interest to note that their effects on plasma glucose level and blood pressure are only observed when these parameters are higher than normal. As steviol can interact with drug transporters, its role as a drug modulator is proposed. This review summarizes the current knowledge of the pharmacological actions, therapeutic applications, pharmacokinetics and safety of stevioside and related compounds. Although much progress has been made concerning their biological and pharmacological effects, questions regarding chemical purity and safety remain unsolved. These issues are discussed to help guide future research directions. © 2008 Elsevier Inc. All rights reserved.