Publication: Characterization and mosquito repellent activity of citronella oil nanoemulsion
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Issued Date
2009-05-08
Resource Type
ISSN
03785173
Other identifier(s)
2-s2.0-64549152449
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Pharmaceutics. Vol.372, No.1-2 (2009), 105-111
Suggested Citation
Usawadee Sakulku, Onanong Nuchuchua, Napaporn Uawongyart, Satit Puttipipatkhachorn, Apinan Soottitantawat, Uracha Ruktanonchai Characterization and mosquito repellent activity of citronella oil nanoemulsion. International Journal of Pharmaceutics. Vol.372, No.1-2 (2009), 105-111. doi:10.1016/j.ijpharm.2008.12.029 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28322
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Title
Characterization and mosquito repellent activity of citronella oil nanoemulsion
Abstract
Encapsulated citronella oil nanoemulsion prepared by high pressure homogenization at varying amounts of surfactant and glycerol, was studied in terms of the droplet size, stability, release characteristics and in vivo mosquito protection. Transparent nanoemulsion can be obtained at optimal concentration of 2.5% surfactant and 100% glycerol. Physical appearance and the stability of the emulsion were greatly improved through an addition of glycerol, owing to its co-solvent and highly viscous property. The increasing emulsion droplet increased the oil retention. The release behavior could be attributed to the effect of droplet size and concentrations of surfactant and glycerol. By fitting to Higuchi's equation, an increase in glycerol and surfactant concentrations resulted in slow release of the oil. The release rate related well to the protection time where a decrease in release rate can prolong mosquito protection time. © 2008 Elsevier B.V. All rights reserved.