Publication:
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

Issued Date

2010-05-01

Resource Type

Article

ISSN

15461718
10614036

DOI

10.1038/ng.567

Other identifier(s)

2-s2.0-77951766379

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Nature Genetics. Vol.42, No.5 (2010), 430-435

Suggested Citation

Rachel M. Freathy, Dennis O. Mook-Kanamori, Ulla Sovio, Inga Prokopenko, Nicholas J. Timpson, Diane J. Berry, Nicole M. Warrington, Elisabeth Widen, Jouke Jan Hottenga, Marika Kaakinen, Leslie A. Lange, Jonathan P. Bradfield, Marjan Kerkhof, Julie A. Marsh, Reedik Mägi, Chih Mei Chen, Helen N. Lyon, Mirna Kirin, Linda S. Adair, Yurii S. Aulchenko, Amanda J. Bennett, Judith B. Borja, Nabila Bouatia-Naji, Pimphen Charoen, Lachlan J.M. Coin, Diana L. Cousminer, Eco J.C. De Geus, Panos Deloukas, Paul Elliott, David M. Evans, Philippe Froguel, Beate Glaser, Christopher J. Groves, Anna Liisa Hartikainen, Neelam Hassanali, Joel N. Hirschhorn, Albert Hofman, Jeff M.P. Holly, Elina Hyppönen, Stavroula Kanoni, Bridget A. Knight, Jaana Laitinen, Cecilia M. Lindgren, Wendy L. McArdle, Paul F. O'Reilly, Craig E. Pennell, Dirkje S. Postma, Anneli Pouta, Adaikalavan Ramasamy, Nigel W. Rayner, Susan M. Ring, Fernando Rivadeneira, Beverley M. Shields, David P. Strachan, Ida Surakka, Anja Taanila, Carla Tiesler, Andre G. Uitterlinden, Cornelia M. Van Duijn, Alet H. Wijga, Gonneke Willemsen, Haitao Zhang, Jianhua Zhao, James F. Wilson, Eric A.P. Steegers, Andrew T. Hattersley, Johan G. Eriksson, Leena Peltonen, Karen L. Mohlke, Struan F.A. Grant, Hakon Hakonarson Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics. Vol.42, No.5 (2010), 430-435. doi:10.1038/ng.567 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28728

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Thesis

Title

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

Author(s)

Rachel M. Freathy
 Dennis O. Mook-Kanamori
 Ulla Sovio
 Inga Prokopenko
 Nicholas J. Timpson
 Diane J. Berry
 Nicole M. Warrington
 Elisabeth Widen
 Jouke Jan Hottenga
 Marika Kaakinen
 Leslie A. Lange
 Jonathan P. Bradfield
 Marjan Kerkhof
 Julie A. Marsh
 Reedik Mägi
 Chih Mei Chen
 Helen N. Lyon
 Mirna Kirin
 Linda S. Adair
 Yurii S. Aulchenko
 Amanda J. Bennett
 Judith B. Borja
 Nabila Bouatia-Naji
 Pimphen Charoen
 Lachlan J.M. Coin
 Diana L. Cousminer
 Eco J.C. De Geus
 Panos Deloukas
 Paul Elliott
 David M. Evans
 Philippe Froguel
 Beate Glaser
 Christopher J. Groves
 Anna Liisa Hartikainen
 Neelam Hassanali
 Joel N. Hirschhorn
 Albert Hofman
 Jeff M.P. Holly
 Elina Hyppönen
 Stavroula Kanoni
 Bridget A. Knight
 Jaana Laitinen
 Cecilia M. Lindgren
 Wendy L. McArdle
 Paul F. O'Reilly
 Craig E. Pennell
 Dirkje S. Postma
 Anneli Pouta
 Adaikalavan Ramasamy
 Nigel W. Rayner
 Susan M. Ring
 Fernando Rivadeneira
 Beverley M. Shields
 David P. Strachan
 Ida Surakka
 Anja Taanila
 Carla Tiesler
 Andre G. Uitterlinden
 Cornelia M. Van Duijn
 Alet H. Wijga
 Gonneke Willemsen
 Haitao Zhang
 Jianhua Zhao
 James F. Wilson
 Eric A.P. Steegers
 Andrew T. Hattersley
 Johan G. Eriksson
 Leena Peltonen
 Karen L. Mohlke
 Struan F.A. Grant
 Hakon Hakonarson

Other Contributor(s)

University of Exeter
 Erasmus University Medical Center
 Imperial College London
 University of Oxford
 Wellcome Trust Centre for Human Genetics
 Medical Research Council
 UCL
 University of Western Australia
 Helsingin Yliopisto
 Vrije Universiteit Amsterdam
 Oulun Yliopisto
 The University of North Carolina at Chapel Hill
 The Children's Hospital of Philadelphia
 University of Groningen, University Medical Center Groningen
 Helmholtz Center Munich German Research Center for Environmental Health
 Klinikum der Universitat Munchen
 Children's Hospital Boston
 Harvard Medical School
 University of Edinburgh
 University of San Carlos
 CNRS Centre National de la Recherche Scientifique
 University of Lille
 Mahidol University
 Wellcome Trust Sanger Institute
 Hammersmith Hospital
 University of Bristol
 Massachusetts Institute of Technology
 Harokopio University
 Tyoterveyslaitos
 University of Western Australia Faculty of Medicine and Dentistry
 National Institute for Health and Welfare
 National Heart and Lung Institute
 University of London
 National Institute of Public Health and the Environment
 Helsinki University Hospital
 Folkhalsan
 National Institute for Health and Welfare
 University of Pennsylvania, School of Medicine
 University Medical Center Groningen, Centre for Revalidation (Beatrix Children's Hospital)
 Churchill Hospital

Abstract

To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 × 10 35) and rs9883204 in ADCY5 (P = 7 × 10 15) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113g (95% CI 89-137g) lighter at birth than the 24% with zero or one alleles (P trend = 7 × 10 30). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy. © 2010 Nature America, Inc. All rights reserved.

Keyword(s)

Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/28728

Collections

Scopus 2006-2010