Publication: Induction of TNF-α in human macrophages by avian and human influenza viruses
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Issued Date
2010-06-09
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ISSN
03048608
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2-s2.0-77955174869
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Mahidol University
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SCOPUS
Bibliographic Citation
Archives of Virology. Vol.155, No.8 (2010), 1273-1279
Suggested Citation
Yuwarat Monteerarat, Saori Sakabe, Somying Ngamurulert, Sirawat Srichatraphimuk, Wasana Jiamtom, Kridsada Chaichuen, Arunee Thitithanyanont, Parichart Permpikul, Taweesak Songserm, Pilaipan Puthavathana, Chairul A. Nidom, Le Quynh Mai, Kiyoko Iwatsuki-Horimoto, Yoshihiro Kawaoka, Prasert Auewarakul Induction of TNF-α in human macrophages by avian and human influenza viruses. Archives of Virology. Vol.155, No.8 (2010), 1273-1279. doi:10.1007/s00705-010-0716-y Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/29218
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Title
Induction of TNF-α in human macrophages by avian and human influenza viruses
Abstract
The highly pathogenic avian influenza virus H5N1 is known to induce high level of tumor necrosis factor α (TNF-α) from primary macrophages. However, it is still unclear whether current H5N1 strains also induce high TNF-α production, as most of the data were derived from extinct clade 0 H5N1 strain. Here, we show that current clade 1 and 2 H5N1 strains induce variable levels of TNF-α that are not necessarily higher than those induced by seasonal influenza viruses. The result suggests that hyper-induction of TNF-α in human macrophages is not always associated with a highly pathogenic phenotype. We further tested the contribution of the NS gene segment from H5N1 isolates to TNF-α induction by using reverse genetics. While NS conferred some variation in TNF-α induction when incorporated into an H1N1 virus genetic background, it did not affect TNF-α induction in an H5N1 virus genetic background, suggesting that other viral genes are involved. © 2010 Springer-Verlag.