Publication: Inhibitory effect of tea polyphenols on local tissue damage induced by snake venoms
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Issued Date
2010-01-01
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ISSN
10991573
0951418X
0951418X
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2-s2.0-75749156920
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytotherapy Research. Vol.24, No.SUPPL. 1 (2010)
Suggested Citation
P. Pithayanukul, J. Leanpolchareanchai, R. Bavovada Inhibitory effect of tea polyphenols on local tissue damage induced by snake venoms. Phytotherapy Research. Vol.24, No.SUPPL. 1 (2010). doi:10.1002/ptr.2903 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/29932
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Title
Inhibitory effect of tea polyphenols on local tissue damage induced by snake venoms
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Abstract
The methanolic extract of fresh tea leaves of Camellia sinensis L. (Theaceae) (CS) was assayed for its potential to inhibit enzymes with hydrolytic activity in Naja naja kaouthia Lesson (Elapidae) and Calloselasma rhodostoma Kuhl (Viperidae) venoms. These snake venom enzymes are responsible for the early effects of envenomation, such as local tissue damage and infl ammation. The CS extract inhibited phospholipase A2, proteases, hyaluronidase and L-amino acid oxidase in both venoms by in vitro neutralization and inhibited the hemorrhagic and the dermonecrotic activities of the venoms in vivo. It is suggested that the inhibitory potential of the CS extract against local tissue damage induced by snake venoms may be attributed to complexation and chelation between the venom proteins and the phenolic contents of the extract. Copyright © 2009 John Wiley & Sons, Ltd.