Publication: The acute hypocalcemic effect of ethanol and its mechanism of action in the rat
Issued Date
1983-01-01
Resource Type
ISSN
00084212
DOI
Other identifier(s)
2-s2.0-0020645918
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Canadian Journal of Physiology and Pharmacology. Vol.61, No.4 (1983), 388-394
Suggested Citation
N. Krishnamra, L. Limlomwongse The acute hypocalcemic effect of ethanol and its mechanism of action in the rat. Canadian Journal of Physiology and Pharmacology. Vol.61, No.4 (1983), 388-394. doi:10.1139/y83-059 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30458
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
The acute hypocalcemic effect of ethanol and its mechanism of action in the rat
Author(s)
Other Contributor(s)
Abstract
The hypocalcemic action of ethanol (3 g/kg body weight) was investigated in intact, thyroparathyroidectomized and antrectomized rats. It was found that ethanol administered either intraperitoneally or orally reduced plasma calcium concentrations within 30 min and that this response lasted for 8 h. Additional studies performed in antrectomized and thyroparathyroidectomized rats indicated that neither gastrin nor the hormones parathormone and calcitonin had any effect on the hypocalcaemic effect of ethanol. Investigation of the mechanism of action of ethanol-induced hypocalcaemia involved measurements of calcium efflux from and influx into the plasma pool. Ethanol did not have any effect on the disappearance from plasma of45Ca administered intravenously at 0 min. In contrast, ethanol was found to enhance the disapperance of45Ca administered intraperitoneally 17 h to the experiment. The interpretation of45Ca studies was discussed and it was concluded that ethanol-induced hypocalcaemia resulted from a decrease in calcium influx into the plasma. Additional in vitro studies did not indicate the suppressive action of ethanol on the release of calcium from tibias. In conclusion, our results show that the mechanism of hypocalcaemia caused by ethanol is the suppression of calcium release from some tissue(s) into the plasma.