Publication: Ferrokinetic and erythrokinetic studies in alpha and beta thalassaemia
2
Issued Date
1984-01-01
Resource Type
ISSN
13652257
01419854
01419854
Other identifier(s)
2-s2.0-0021166120
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical & Laboratory Haematology. Vol.6, No.2 (1984), 133-140
Suggested Citation
T. SRICHAIKUL, J. TIPAYASAKDA, V. ATICHARTAKARN, S. JOOTAR, P. BOVORNBINYANUN Ferrokinetic and erythrokinetic studies in alpha and beta thalassaemia. Clinical & Laboratory Haematology. Vol.6, No.2 (1984), 133-140. doi:10.1111/j.1365-2257.1984.tb00535.x Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30700
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Title
Ferrokinetic and erythrokinetic studies in alpha and beta thalassaemia
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Abstract
Summary. Ferrokinetic and erythrokinetic studies were performed in 25 non‐splenectomized patients with alpha or beta thalassaemia. Nine of these had HbH disease and six had HbE/β thalassaemia or homozygous β thalassaemia. In HbH disease, a mild anaemia was associated with severe peripheral haemolysis, increased splenic sequestration and only a moderate degree of ineffective erythropoiesis. By contrast, in the beta thalassaemia syndromes, a more marked anaemia was associated with prominent ineffective erythropoiesis and mild peripheral haemolysis. These findings indicate that the pathogenesis of anaemia in alpha and beta thalassaemia is different, haemolysis dominating in HbH disease and ineffective erythropoiesis in HbE/β thalassaemia and homozygous β thalassaemia. Copyright © 1984, Wiley Blackwell. All rights reserved