Publication: Comparative studies on thymidylate synthetase from P. berghei and mouse reticulocytes
1
Issued Date
1985-01-01
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ISSN
03050491
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2-s2.0-0021904294
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Mahidol University
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SCOPUS
Bibliographic Citation
Comparative Biochemistry and Physiology -- Part B: Biochemistry and. Vol.80, No.3 (1985), 583-587
Suggested Citation
Sa Nga Pattanakitsakul, Adisorn Ratanaphan, Pintip Ruenwongsa Comparative studies on thymidylate synthetase from P. berghei and mouse reticulocytes. Comparative Biochemistry and Physiology -- Part B: Biochemistry and. Vol.80, No.3 (1985), 583-587. doi:10.1016/0305-0491(85)90295-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/30745
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Title
Comparative studies on thymidylate synthetase from P. berghei and mouse reticulocytes
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Abstract
1. 1. Partially purified thymidylate synthetase from Plasmodium berghei and mouse reticulocytes was characterized. 2. 2. The mol. wt of the enzyme from P. berghei was about twice that from mouse reticulocytes. 3. 3. The optimum pH of the enzyme from P. berghei was found to be 6.5-7.5 while that from the host was 7.0-8.0. 4. 4. The enzyme from P. berghei was more susceptible to pH denaturation than the enzyme from reticulocytes. 5. 5. The enzyme from both sources differed in their Kmvalues for substrates. 6. 6. The enzyme from reticulocytes was less sensitive to inhibition by substrate analogs than that from P. berghei. © 1985.