Publication: Questions over high frequency of mutant PfATP6
haplotypes in traveller isolates
3
Issued Date
2012
Resource Type
Language
eng
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Mahidol University
Rights Holder(s)
BioMed Central
Bibliographic Citation
Malaria Journal. Vol.11, (2012),186
Suggested Citation
Woodrow, Charles J, Gardner, Kate B, Bustamante, Leyla Y Questions over high frequency of mutant PfATP6
haplotypes in traveller isolates. Malaria Journal. Vol.11, (2012),186. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/3100
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Title
Questions over high frequency of mutant PfATP6
haplotypes in traveller isolates
Abstract
A recent paper in Malaria Journal suggests that a high proportion of Plasmodium falciparum isolates found in
travellers returning from a range of African countries carry the PfATP6 A623E S769N haplotype, and that this
genotype is associated with artemether resistance. Such a finding would represent a substantial departure from the
extensive literature reporting these individual mutations to be very rare, with the double mutation never
documented. The number of isolates screened to obtain these double mutants is unstated, but highly relevant, not
least because selection of isolates could have introduced significant confounders, such as timing of in vitro testing.
An additional concern relates to the location of sequencing primers used to assess these positions. In the absence
of clear information on these fundamental questions it would be appropriate to treat the findings with caution.