Publication: Total phenolics and total flavonoids contents and hypnotic effect in mice of Ziziphus mauritIana Lam. seed extract
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Issued Date
2013-06-28
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17414288
1741427X
1741427X
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2-s2.0-84879313779
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Mahidol University
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SCOPUS
Bibliographic Citation
Evidence-based Complementary and Alternative Medicine. Vol.2013, (2013)
Suggested Citation
Aye Moh Moh San, Suchitra Thongpraditchote, Pongtip Sithisarn, Wandee Gritsanapan Total phenolics and total flavonoids contents and hypnotic effect in mice of Ziziphus mauritIana Lam. seed extract. Evidence-based Complementary and Alternative Medicine. Vol.2013, (2013). doi:10.1155/2013/835854 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/32286
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Total phenolics and total flavonoids contents and hypnotic effect in mice of Ziziphus mauritIana Lam. seed extract
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Abstract
The seeds of Ziziphus mauritiana Lam. have been traditionally used for treatment of various complications including insomnia and anxiety. They are popularly used as sedative and hypnotic drugs in China, Korea, Myanmar, Vietnam, and other Asian countries. However, no scientific proof on hypnotic activity of Z. mauritiana seeds (ZMS) was reported. In this study, the hypnotic activity of 50% ethanolic extract from ZMS was observed on the loss of righting reflex in mice using pentobarbital-induced sleep mice method. The contents of total phenolics and total flavonoids in the extract were also determined. The results showed that the 50% ethanolic extract from ZMS contained total phenolics 27.62 ± 1.43 mg gallic acid equivalent (GAE)/g extract and total flavonoids 0.74 ± 0.03 mg quercetin equivalent (QE)/g extract. Oral administration of the extract at the dose of 200 mg/kg significantly increased the sleeping time in mice intraperitoneally administered with sodium pentobarbital (50 mg/kg body weight). These results supported the traditional use of ZMS for the treatment of insomnia. The seeds of Z. mauritiana should be further developed as an alternative sedative and/or hypnotic product. © 2013 Aye Moh Moh San et al.