Publication: Genetic diversity of the rat lungworm, Angiostrongylus cantonensis, the major cause of eosinophilic meningitis.
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Issued Date
2013-06-01
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21658242
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2-s2.0-84900929942
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Mahidol University
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SCOPUS
Bibliographic Citation
Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health. Vol.72, No.6 Suppl 2 (2013), 15-17
Suggested Citation
Praphathip Eamsobhana, Phaik Eem Lim, Hoi Sen Yong Genetic diversity of the rat lungworm, Angiostrongylus cantonensis, the major cause of eosinophilic meningitis.. Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health. Vol.72, No.6 Suppl 2 (2013), 15-17. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/32307
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Title
Genetic diversity of the rat lungworm, Angiostrongylus cantonensis, the major cause of eosinophilic meningitis.
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Abstract
Various aspects of the genetics of the rat lungworm, Angiostrongylus cantonensis, are reviewed. This nematode has an XX/XO sex-determination mechanism, with the female having a 2n = 12 (XX) and the male 2n = 11 (XO) chromosome constitution. Allozymes (12 loci) exhibit a low proportion of polymorphic loci (P = .08) and low mean heterozygosity (H = 0.43) in specimens from Hawa'i, and no polymorphism or heterozygosity in specimens from Thailand. The phosphoglucomutase-2 (PGM-2) locus exhibits sex-limited expression, with no detectable enzyme activity in the male worms from either location. Based on the 12 allozyme loci, Nei's genetic distance between the Hawa'i and Thailand isolates is D = 0.03. The p-distance (proportion of nucleotide sites) based on cytochrome c oxidase subunit I (COI) is 3.61% between the Thailand and China isolates as well as between Thailand and Hawa'i isolates, and 0.83% between China and Hawa'i isolates. The partial DNA sequences of the 66 kDa protein gene show a great diversity of haplotypes, indicating both inter- and intra-population variation. Intra-specific sequence variation is also found in the internal transcribed spacer regions. For the small-subunit ribosomal RNA (SSU rRNA) gene, two distinct genotypes have been recorded.