Publication: Annular leukocytoclastic vasculitis associated with anti-tuberculosis medications: A case report
Issued Date
2013-02-04
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ISSN
17521947
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2-s2.0-84873026634
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Medical Case Reports. Vol.7, (2013)
Suggested Citation
Kumutnart Chanprapaph, Wanjarus Roongpisuthipong, Kunlawat Thadanipon Annular leukocytoclastic vasculitis associated with anti-tuberculosis medications: A case report. Journal of Medical Case Reports. Vol.7, (2013). doi:10.1186/1752-1947-7-34 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/32496
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Title
Annular leukocytoclastic vasculitis associated with anti-tuberculosis medications: A case report
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Abstract
Introduction. Anti-tuberculosis drug-induced cutaneous leukocytoclastic vasculitis has been rarely reported. To the best of our knowledge, this is the first reported case of annular leukocytoclastic vasculitis associated with anti-tuberculosis drug administration. Case presentation. We report a case of annular leukocytoclastic vasculitis induced by anti-tuberculosis medication. A 62-year-old Thai man presented to our facility with a generalized exanthematous rash on his trunk and extremities that resolved shortly afterwards. Subsequently, he developed multiple, erythematous-to-purplish, non-blanchable macules and papules with an annular arrangement on his extremities. The skin rash occurred after two weeks of anti-tuberculosis medication. The histopathology of the purpuric skin lesion was consistent with leukocytoclastic vasculitis. The skin lesion improved after discontinuation of the anti-tuberculosis drugs and treatment with oral antihistamine and topical corticosteroid drugs. Streptomycin, ethambutol and ofloxacin were administered as second-line anti-tuberculosis therapy during his hospitalization. No adverse reactions were observed. Conclusions: Leukocytoclastic vasculitis should be considered in the differential diagnosis of annular non-blanchable macules and papules. Although rare, anti-tuberculosis drugs should be considered potential causes of drug-induced annular leukocytoclastic vasculitis. © 2013 Chanprapaph et al.; licensee BioMed Central Ltd.