Publication: Zederone, a sesquiterpene from curcuma elata roxb, is hepatotoxic in mice
2
Issued Date
2013-11-01
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ISSN
1092874X
10915818
10915818
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2-s2.0-84889826512
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Toxicology. Vol.32, No.6 (2013), 454-462
Suggested Citation
Prapapan Pimkaew, Kanoknetr Suksen, Koravit Somkid, Ratchanaporn Chokchaisiri, Surawat Jariyawat, Aporn Chuncharunee, Apichart Suksamrarn, Pawinee Piyachaturawat Zederone, a sesquiterpene from curcuma elata roxb, is hepatotoxic in mice. International Journal of Toxicology. Vol.32, No.6 (2013), 454-462. doi:10.1177/1091581813504595 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/32726
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Title
Zederone, a sesquiterpene from curcuma elata roxb, is hepatotoxic in mice
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Abstract
The present study aimed to investigate the hepatotoxicity of zederone isolated from Curcuma elata in mice. Adult male mice were intraperitoneally injected with a single dose of zederone (50-300 mg/kg body weight [BW]). Twenty-four hours after the injection, zederone induced liver enlargement with scattered white foci over the organ. The medium lethal dose (LD50) value at 24 hours of zederone was approximately 223 mg/kg BW. Hepatic centrilobular necrosis with marked increases in plasma alanine transaminase activity and total bilirubin levels was observed. Zederone at a dose of 200 mg/kg BW markedly decreased the activity of superoxide dismutase and the hepatic glutathione content, whereas the activity of catalase was not altered. The compound at this dose also increased the messenger RNA (mRNA) expression of Cyp2b10 and Cyp3a11, which are the main drug-metabolizing enzymes in the liver. The mRNA expression of proinflammatory cytokine tumor necrosis factor α was increased. The nuclear factor-E2-related factor 2 protein, which is the transcription factor regulating the antioxidant gene expression, was decreased. The histopathology of massive hepatic centrilobular necrosis with an increase in the expression of cytochrome P450 (Cyp) suggests that the possible potentiation of zederone-induced hepatotoxicity implicated the induction of Cyps, which leads to the formation of biological reactive metabolites and that cause the oxidative stress and liver cell injuries. © 2013 The Author(s).