Publication: Defective bone microstructure in hydronephrotic mice: A histomorphometric study in ICR/Mlac-hydro mice
Submitted Date
Received Date
Accepted Date
Issued Date
2014-02-01
Copyright Date
Announcement No.
Application No.
Patent No.
Valid Date
Resource Type
Edition
Resource Version
Language
File Type
No. of Pages/File Size
ISBN
ISSN
19328494
19328486
19328486
eISSN
DOI
Scopus ID
WOS ID
Pubmed ID
arXiv ID
Call No.
Other identifier(s)
2-s2.0-84892671662
Journal Title
Volume
Issue
item.page.oaire.edition
Start Page
End Page
Access Rights
Access Status
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Physical Location
Bibliographic Citation
Anatomical Record. Vol.297, No.2 (2014), 208-214
Citation
Panan Suntornsaratoon, Kannikar Wongdee, Wacharaporn Tiyasatkulkovit, Sumate Ampawong, Nateetip Krishnamra, Kanchana Kengkoom, Narattaphol Charoenphandhu (2014). Defective bone microstructure in hydronephrotic mice: A histomorphometric study in ICR/Mlac-hydro mice. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/33059.
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Defective bone microstructure in hydronephrotic mice: A histomorphometric study in ICR/Mlac-hydro mice
Alternative Title(s)
Author's Affiliation
Author's E-mail
Editor(s)
Editor's Affiliation
Corresponding Author(s)
Creator(s)
Compiler
Advisor(s)
Illustrator(s)
Applicant(s)
Inventor(s)
Issuer
Assignee
Other Contributor(s)
Series
Has Part
Abstract
Chronic renal impairment can lead to bone deterioration and abnormal bone morphology, but whether hydronephrosis is associated with bone loss remains unclear. Herein, we aimed to use computer-assisted bone histomorphometric technique to investigate microstructural bone changes in Imprinting Control Region (ICR) mice with a spontaneous mutation that was associated with bilateral nonobstructive hydronephrosis (ICR/Mlac-hydro). The results showed that 8-week-old ICR/Mlac-hydro mice manifested decreases in trabecular bone number and thickness, and an increased trabecular separation, thereby leading to a reduction in trabecular bone volume compared with the wild-type mice. Furthermore, histomorphometric parameters related to both bone resorption and formation, that is, eroded surface, osteoclast surface, and osteoblast surface, were much lower in ICR/Mlac-hydro mice than in the wild type. A decrease in moment of inertia was found in ICR/Mlac-hydro mice, indicating a decrease in bone strength. In conclusion, ICR/Mlac-hydro mice exhibited trabecular bone loss, presumably caused by marked decreases in both osteoblast and osteoclast activities, which together reflected abnormally low bone turnover. Thus, this mouse strain appeared to be a valuable model for studying the hydronephrosis-associated bone disease. © 2013 Wiley Periodicals, Inc.