Publication: Clinical and laboratory update on the DEL variant
1
Issued Date
2014-11-01
Resource Type
ISSN
19437730
00075027
00075027
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2-s2.0-84949645271
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Mahidol University
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SCOPUS
Bibliographic Citation
Laboratory Medicine. Vol.45, No.4 (2014), 285-290
Suggested Citation
Pornlada Nuchnoi, Jairak Thongbus, Apapan Srisarin, Usanee Kerdpin, Virapong Prachayasittikul Clinical and laboratory update on the DEL variant. Laboratory Medicine. Vol.45, No.4 (2014), 285-290. doi:10.1309/LMTUZ00O7VFTGCEB Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/33211
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Title
Clinical and laboratory update on the DEL variant
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Abstract
Serological assays for the RhD blood group are based on detection of the RhD antigen on human red blood cells using a specific anti-D antibody. The weak expression of the RhD antigen in the DEL variant hinders the sensitivity of conventional serological assays. Evidence of anti-D immunization in patients with D-negativity who have received DEL-variant blood units has been reported in various populations. This observation has prompted the need for genetic epidemiological and clinical data on the DEL variant in the development of DEL molecular diagnostic testing. This review highlights the molecular features of the DEL variant, the clinical consequences of DEL-blood transfusion, and current approaches for detection of the DEL-variant for donor screening and transfusion.