Publication: Optical readout of the intracellular environment using nanoparticle transducers
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Issued Date
2014-01-01
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ISSN
18793096
01677799
01677799
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2-s2.0-84908215502
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Mahidol University
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SCOPUS
Bibliographic Citation
Trends in Biotechnology. Vol.32, No.11 (2014), 571-577
Suggested Citation
Annette Dowd, Dakrong Pissuwan, Michael B. Cortie Optical readout of the intracellular environment using nanoparticle transducers. Trends in Biotechnology. Vol.32, No.11 (2014), 571-577. doi:10.1016/j.tibtech.2014.09.004 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/33349
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Title
Optical readout of the intracellular environment using nanoparticle transducers
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Abstract
© 2014 Published by Elsevier Ltd. There is rapid growth in the use of multi-functional nanoparticles as transducers to probe the intracellular environment. New designs of nanoparticles can provide quantitative information at sub-cellular resolution on parameters such as pH, temperature and concentration of nicotinamide adenine dinucleotide (NADH) or selected metal ions. This new work builds on the existing practice of using nanoparticles and fluorescent dyes to provide enhanced microscopic images of cells, but goes beyond it by adding new functionalities and analytical capabilities. In this review, we discuss the recent literature on the development of such nanoparticles for simultaneous biosensing and imaging. We explore and examine the different measurements that will be possible, and analyze the likely accuracy and resolution that could be achieved.