Publication: The effect of surfactant composition on the chemical and structural properties of nanostructured lipid carriers
1
Issued Date
2014-01-01
Resource Type
ISSN
14645246
02652048
02652048
Other identifier(s)
2-s2.0-84906559080
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Microencapsulation. Vol.31, No.6 (2014), 609-618
Suggested Citation
Kullavadee Karn-Orachai, Siwaporn Meejoo Smith, Sarunya Phunpee, Alongkot Treethong, Satit Puttipipatkhachorn, Sirapat Pratontep, Uracha Rungsardthong Ruktanonchai The effect of surfactant composition on the chemical and structural properties of nanostructured lipid carriers. Journal of Microencapsulation. Vol.31, No.6 (2014), 609-618. doi:10.3109/02652048.2014.911374 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/33602
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
The effect of surfactant composition on the chemical and structural properties of nanostructured lipid carriers
Abstract
Fine-tuning the nanoscale structure and morphology of nanostructured lipid carriers (NLCs) is central to improving drug loading and stability of the particles. The role of surfactant charge on controlling the structure, the physicochemical properties and the stability of NLCs has been investigated using three surfactant types (cationic, anionic, non-ionic), and mixed surfactants. Either one, a mixture of two, or a mixture of three surfactants were used to coat the NLCs, with these classified as one, two and three surfactant systems, respectively. The mixed (two and three) surfactant systems produced smaller NLC particles and yielded NLCs with lower crystallinity than the one surfactant system. The combined effects of the ionic and the non-ionic surfactants may play a key role in assisting the lipid-oil mixing, as well as maintaining colloidal repulsion between NLC particles. In contrast, for the three surfactant system, the lipid-oil mixture in the NLCs appeared less homogenous. This was also reflected in the results of the stability study, which indicated that NLC particle sizes in two surfactant systems appeared to be retained over longer periods than for other surfactant systems. © 2014 Informa UK Ltd.