Publication: Characterization of human immunodeficiency virus type 1 CRF01_AE env genes derived from recently infected Thai individuals
1
Issued Date
2014-02-01
Resource Type
ISSN
1769714X
12864579
12864579
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2-s2.0-84894971811
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Mahidol University
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SCOPUS
Bibliographic Citation
Microbes and Infection. Vol.16, No.2 (2014), 142-152
Suggested Citation
Nithinart Chaitaveep, Piraporn Utachee, Shota Nakamura, Thippawan Chuenchitra, Pattama Ekpo, Naokazu Takeda, Kovit Pattanapanyasat, Masanori Kameoka Characterization of human immunodeficiency virus type 1 CRF01_AE env genes derived from recently infected Thai individuals. Microbes and Infection. Vol.16, No.2 (2014), 142-152. doi:10.1016/j.micinf.2013.10.015 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/33997
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Title
Characterization of human immunodeficiency virus type 1 CRF01_AE env genes derived from recently infected Thai individuals
Abstract
Transmitted/founder virus is responsible for the establishment of human immunodeficiency virus type 1 (HIV-1) infection and induces primary anti-HIV-1 immune responses; therefore, it is important to study the viral population to understand the early events of HIV-1 infection. We amplified HIV-1 env genes from sera derived from recently infected Thai individuals, and established envelope glycoproteins (Env)-recombinant viruses. Generated Env-recombinant viruses were tested for their neutralization susceptibility to neutralizing human monoclonal antibodies (NHMAbs) and entry inhibitors, as well as being subjected to genotypic analysis. Most recombinant viruses were susceptible to neutralization by NHMAbs to Env gp41, whereas approximately one-third of the recombinant viruses were susceptible to a NHMAb against the CD4 binding site of gp120. In addition, all env genes were classified into CRF01_AE genes and showed low genetic divergence. Taken together with our previous studies on CRF01_AE env genes derived from chronically infected Thai individuals, these results suggested that the immunological and genetic characteristics of CRF01_AE Env derived from recently infected Thai individuals were different from those derived from chronically infected individuals. © 2013 Institut Pasteur.