Publication: Treatment of suspected hyper-reactive malarial splenomegaly (HMS) in pregnancy with mefloquine
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Issued Date
2014-01-01
Resource Type
ISSN
00029637
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2-s2.0-84898757143
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.90, No.4 (2014), 609-611
Suggested Citation
Juthamas Jaroensuk, Nicole Stoesser, Mara L. Leimanis, Podjanee Jittamala, Nicholas J. White, Francois H. Nosten, Rose McGready Treatment of suspected hyper-reactive malarial splenomegaly (HMS) in pregnancy with mefloquine. American Journal of Tropical Medicine and Hygiene. Vol.90, No.4 (2014), 609-611. doi:10.4269/ajtmh.13-0706 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/34087
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Title
Treatment of suspected hyper-reactive malarial splenomegaly (HMS) in pregnancy with mefloquine
Abstract
Malaria infections in pregnancy are associated with adverse outcomes for both mother and child. There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy. This retrospective assessment reviewed the impact of mefloquine treatment on pregnant women with suspected hyper-reactive malarial splenomegaly in an area of low malaria transmission in the 1990s, showing significant reductions in spleen size and anemia and anti-malarial antibody titers without any notable negative effect on treated women or their newborns. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.