Publication: Evaluation of the diagnostic accuracy of a typhoid IgM flow assay for the diagnosis of typhoid fever in Cambodian children using a Bayesian latent class model assuming an imperfect gold standard
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Issued Date
2014-01-01
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ISSN
00029637
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2-s2.0-84892681513
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.90, No.1 (2014), 114-120
Suggested Citation
Catrin E. Moore, Wirichada Pan-Ngum, Lalith P.M. Wijedoru, Soeng Sona, Tran Vu Thieu Nga, Pham Thanh Duy, Phat Voong Vinh, Kheng Chheng, Varun Kumar, Kate Emary, Michael Carter, Lisa White, Stephen Baker, Nicholas P.J. Day, Christopher M. Parry Evaluation of the diagnostic accuracy of a typhoid IgM flow assay for the diagnosis of typhoid fever in Cambodian children using a Bayesian latent class model assuming an imperfect gold standard. American Journal of Tropical Medicine and Hygiene. Vol.90, No.1 (2014), 114-120. doi:10.4269/ajtmh.13-0384 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/34099
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Title
Evaluation of the diagnostic accuracy of a typhoid IgM flow assay for the diagnosis of typhoid fever in Cambodian children using a Bayesian latent class model assuming an imperfect gold standard
Abstract
Rapid diagnostic tests are needed for typhoid fever (TF) diagnosis in febrile children in endemic areas. Five hundred children admitted to the hospital in Cambodia between 2009 and 2010 with documented fever (≥38 ° C) were investigated using blood cultures (BCs), Salmonella Typhi/Paratyphi A real-time polymerase chain reactions (PCRs), and a Typhoid immunoglobulin M flow assay (IgMFA). Test performance was determined by conventional methods and Bayesian latent class modeling. There were 32 cases of TF (10 BC- and PCR-positive cases, 14 BC-positive and PCR-negative cases, and 8 BC-negative and PCR-positive cases). IgMFA sensitivity was 59.4% (95% confidence interval = 41-76), and specificity was 97.8% (95% confidence interval = 96-99). The model estimate sensitivity for BC was 81.0% (95% credible interval = 54-99). The model estimate sensitivity for PCR was 37.8% (95% credible interval = 26-55), with a specificity of 98.2% (95% credible interval = 97-99). The model estimate sensitivity for IgMFA (≥2+) was 77.9% (95% credible interval = 58-90), with a specificity of 97.5% (95% credible interval = 95-100). The model estimates of IgMFA sensitivity and specificity were comparable with BCs and better than estimates using conventional analysis. Copyright © 2014 by The American Society of Tropical Medicine and Hygiene.