Publication:
Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV observational database

2

Issued Date

2014-09-01

Resource Type

Article

ISSN

10779450
15254135

DOI

10.1097/QAI.0000000000000227

Other identifier(s)

2-s2.0-84906085101

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Acquired Immune Deficiency Syndromes. Vol.67, No.1 (2014), 71-76

Suggested Citation

Azar Kariminia, Nicolas Durier, Gonzague Jourdain, Suneeta Saghayam, Chau V. Do, Lam Van Nguyen, Rawiwan Hansudewechakul, Pagakrong Lumbiganon, Kulkanya Chokephaibulkit, Khanh Huu Truong, Virat Sirisanthana, Vibol Ung, Saphonn Vonthanak, Jintanat Ananworanich, Nik Khairulddin Nik Yusoff, Nia Kurniati, Kamarul Azahar Razali, Moy Siew Fong, Revathy Nallusamy, Dewi Kumara Wati Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV observational database. Journal of Acquired Immune Deficiency Syndromes. Vol.67, No.1 (2014), 71-76. doi:10.1097/QAI.0000000000000227 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/34205

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Title

Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV observational database

Author(s)

Azar Kariminia
 Nicolas Durier
 Gonzague Jourdain
 Suneeta Saghayam
 Chau V. Do
 Lam Van Nguyen
 Rawiwan Hansudewechakul
 Pagakrong Lumbiganon
 Kulkanya Chokephaibulkit
 Khanh Huu Truong
 Virat Sirisanthana
 Vibol Ung
 Saphonn Vonthanak
 Jintanat Ananworanich
 Nik Khairulddin Nik Yusoff
 Nia Kurniati
 Kamarul Azahar Razali
 Moy Siew Fong
 Revathy Nallusamy
 Dewi Kumara Wati

Other Contributor(s)

University of New South Wales (UNSW) Australia
 TREAT Asia/amfAR-The Foundation for AIDS Research
 IRD Institut de Recherche pour le Developpement
 Chiang Mai University
 YR Gaitonde Centre for AIDS Research and Education
 Children's Hospital 2
 National Hospital of Pediatrics Hanoi
 Chiangrai Prachanukroh Hospital
 Khon Kaen University
 Mahidol University
 Children's Hospital 1
 National Pediatric Hospital
 National Center for HIV/AIDS
 The HIV Netherlands Australia Thailand Research Collaboration
 Hospital Raja Perempuan Zainab II
 University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
 Kuala Lumpur Hospital
 Hospital Likas
 Penang Hospital
 Universitas Udayana

Abstract

Objective: To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART). Methods: We used Cox regression to analyze data of a cohort of Asian children. Results: A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score <-3 was associated with mortality (P < 0.001) independent of CD4% and <-2 was associated with immunological failure (P ≤ 0.03) independent of age at cART. Conclusions: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings. © 2014 by Lippincott Williams & Wilkins.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/34205

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