Publication:
Plasmo View: A web-based resource to visualise global Plasmodium falciparum genomic variation

1

Issued Date

2014-06-01

Resource Type

Article

ISSN

15376613
00221899

DOI

10.1093/infdis/jit812

Other identifier(s)

2-s2.0-84900791013

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Infectious Diseases. Vol.209, No.11 (2014), 1808-1815

Suggested Citation

Mark D. Preston, Samuel A. Assefa, Harold Ocholla, Colin J. Sutherland, Steffen Borrmann, Alexis Nzila, Pascal Michon, Tran Tinh Hien, Teun Bousema, Christopher J. Drakeley, Issaka Zongo, Jean Bosco Ouédraogo, Abdoulaye A. Djimde, Ogobara K. Doumbo, Francois Nosten, Rick M. Fairhurst, David J. Conway, Cally Roper, Taane G. Clark Plasmo View: A web-based resource to visualise global Plasmodium falciparum genomic variation. Journal of Infectious Diseases. Vol.209, No.11 (2014), 1808-1815. doi:10.1093/infdis/jit812 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/34243

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Plasmo View: A web-based resource to visualise global Plasmodium falciparum genomic variation

Author(s)

Mark D. Preston
 Samuel A. Assefa
 Harold Ocholla
 Colin J. Sutherland
 Steffen Borrmann
 Alexis Nzila
 Pascal Michon
 Tran Tinh Hien
 Teun Bousema
 Christopher J. Drakeley
 Issaka Zongo
 Jean Bosco Ouédraogo
 Abdoulaye A. Djimde
 Ogobara K. Doumbo
 Francois Nosten
 Rick M. Fairhurst
 David J. Conway
 Cally Roper
 Taane G. Clark

Other Contributor(s)

London School of Hygiene & Tropical Medicine
 Malawi-Liverpool-Wellcome Trust Clinical Research Programme
 Liverpool School of Tropical Medicine
 Wellcome Trust Research Laboratories Nairobi
 Universitat Heidelberg
 King Fahd University of Petroleum and Minerals
 Papua New Guinea Institute of Medical Research
 UCL
 Institut de Recherche en Sciences de la Santé
 University of Bamako Faculty of Medicine, Pharmacy and Odonto-Stomatology
 Wellcome Trust Sanger Institute
 Mahidol University
 University of Oxford
 Shoklo Malaria Research Unit
 National Institute of Allergy and Infectious Diseases

Abstract

Malaria is a global public health challenge, with drug resistance a major barrier to disease control and elimination. To meet the urgent need for better treatments and vaccines, a deeper knowledge of Plasmodium biology and malaria epidemiology is required. An improved understanding of the genomic variation of malaria parasites, especially the most virulent Plasmodium falciparum (Pf) species, has the potential to yield new insights in these areas. High-throughput sequencing and genotyping is generating large amounts of genomic data across multiple parasite populations. The resulting ability to identify informative variants, particularly single-nucleotide polymorphisms (SNPs), will lead to the discovery of intra- and inter-population differences and thus enable the development of genetic barcodes for diagnostic assays and clinical studies. Knowledge of genetic variability underlying drug resistance and other differential phenotypes will also facilitate the identification of novel mutations and contribute to surveillance and stratified medicine applications. The PlasmoView interactive web-browsing tool enables the research community to visualise genomic variation and annotation (eg, biological function) in a geographic setting. The first release contains over 600 000 high-quality SNPs in 631 Pf isolates from laboratory strains and four malaria-endemic regions (West Africa, East Africa, Southeast Asia and Oceania). © 2013 The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/34243

Collections

Scopus 2011-2015