Publication:
Characterizing HIV manifestations and treatment outcomes of perinatally infected adolescents in Asia

Issued Date

2014-03-01

Resource Type

Article

ISSN

15320987

DOI

10.1097/INF.0b013e3182a18223

Other identifier(s)

2-s2.0-85028266230

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

The Pediatric infectious disease journal. Vol.33, No.3 (2014), 291-294

Suggested Citation

Kulkanya Chokephaibulkit, Azar Kariminia, Peninnah Oberdorfer, Revathy Nallusamy, Torsak Bunupuradah, Rawiwan Hansudewechakul, Khu T.hi Khanh Dung, Vonthanak Saphonn, Nagalingeswaran Kumarasamy, Pagakrong Lumbiganon, Do C.hau Viet, Nia Kurniati, Nik K.hairuddin Nik Yusoff, Kamarul Razali, Siew M.oy Fong, Truong H.uu Khanh, Dewi K.umara Wati, Annette H. Sohn Characterizing HIV manifestations and treatment outcomes of perinatally infected adolescents in Asia. The Pediatric infectious disease journal. Vol.33, No.3 (2014), 291-294. doi:10.1097/INF.0b013e3182a18223 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/34283

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Title

Characterizing HIV manifestations and treatment outcomes of perinatally infected adolescents in Asia

Author(s)

Kulkanya Chokephaibulkit
 Azar Kariminia
 Peninnah Oberdorfer
 Revathy Nallusamy
 Torsak Bunupuradah
 Rawiwan Hansudewechakul
 Khu T.hi Khanh Dung
 Vonthanak Saphonn
 Nagalingeswaran Kumarasamy
 Pagakrong Lumbiganon
 Do C.hau Viet
 Nia Kurniati
 Nik K.hairuddin Nik Yusoff
 Kamarul Razali
 Siew M.oy Fong
 Truong H.uu Khanh
 Dewi K.umara Wati
 Annette H. Sohn

Other Contributor(s)

Mahidol University

Abstract

BACKGROUND: More perinatally HIV-infected children in Asia are reaching adolescence.METHODS: We analyzed data from July 1991 to March 2011 reported by 18 clinics in 6 countries of children age >12 years.RESULTS: Of 1254 adolescents, 33 (2.6%) died, and 52 (4.1%) were lost to follow-up within 2.4-year (3566 person-years) median follow-up period. Of 1061 adolescents under active follow-up, 485 (46%) were male, median (interquartile range) age was 14.7 (13.3-16.4) years, 73% had lost a parent(s), 93% attended school and 62% were aware of their HIV status. At the most recent evaluation, 93% were receiving highly active antiretroviral therapy, 71% (N = 737/1035) had CD4 ≥ 500 cells/mm(3) and 87% (N = 718/830) had viral load (VL) <400 copies/mL. Current CD4 ≥ 200 cells/mm(3), no previous World Health Organization stage 3 or 4 and being on a first-line regimen were independently associated with recent VL <400 copies/mL. Current age <15 years, VL <400 copies/mL, CD4 15-24% (vs. <10%) at antiretroviral therapy initiation, no previous World Health Organization stage 3 or 4 and antiretroviral therapy duration of ≥ 1 year were associated with recent CD4 ≥ 500 cells/mm(3). Primary causes of death after age 12 were opportunistic infections (N = 15/33) and other AIDS- or treatment-related conditions (N = 9/33). Those at age 12 with CD4 <200 versus ≥ 500 cells/mm and those with VL ≥ 10,000 versus <10,000 copies/mL were 17.4 and 4.76 times more likely to die in adolescence, respectively.CONCLUSION: Adolescents in this cohort have been successfully maintained in HIV care. Initiating treatment at earlier stages of disease was associated with immune recovery and virologic suppression during adolescence.

Keyword(s)

Medicine

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https://repository.li.mahidol.ac.th/handle/123456789/34283

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