Publication: SOX-10 and MiTF expression in cellular and 'mixed' neurothekeoma
Issued Date
2014-01-01
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ISSN
16000560
03036987
03036987
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2-s2.0-84904980498
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Cutaneous Pathology. Vol.41, No.8 (2014), 640-645
Suggested Citation
Isabella Fried, Panitta Sitthinamsuwan, Sorranart Muangsomboon, Steven Kaddu, Lorenzo Cerroni, Timothy H. McCalmont SOX-10 and MiTF expression in cellular and 'mixed' neurothekeoma. Journal of Cutaneous Pathology. Vol.41, No.8 (2014), 640-645. doi:10.1111/cup.12301 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/34688
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Title
SOX-10 and MiTF expression in cellular and 'mixed' neurothekeoma
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Abstract
Background Neurothekeoma and nerve sheath myxoma have long been interpreted as related tumors that share nerve sheath linage. Lack of S100 expression in neurothekeoma and similarities of gene expression profiles between neurothekeoma and fibrohistiocytic tumors have created reasonable doubt about this concept. SOX-10 represents a marker for schwannian and melanocytic differentiation, and is expressed in other tumors of nerve sheath linage. Microphthalmia transcription factor (MiTF) expression has been repeatedly reported in cellular neurothekeoma in the recent literature and was proposed as a helpful marker in this entity. Methods We investigated 25 cases of cellular neurothekeoma, 8 cases of mixed neurothekeoma and 1 case of nerve sheath myxoma for the expression of SOX-10, MiTF, S100, NKI/C3, Melan-A and smooth muscle actin (SMA) using immunohistochemistry. Results A lack of SOX-10 expression was demonstrated in 100% of cellular and mixed neurothekeomas, but was present in the case of nerve sheath myxoma. More than two thirds of neurothekeomas showed very focal or no reactivity with MiTF. Conclusions Our data suggest that neurothekeoma and nerve sheath myxoma are unrelated, and that cellular and mixed neurothekeoma may not be of nerve sheath lineage. In addition, MiTF should not be regarded as a useful marker in neurothekeoma. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.