Publication: A model for the testosterone regulation taking into account the presence of two types of testosterone hormones
Issued Date
2015-01-01
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ISSN
02183390
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2-s2.0-84930178662
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Biological Systems. Vol.23, No.2 (2015), 259-273
Suggested Citation
T. Tanutpanit, P. Pongsumpun, I. M. Tang A model for the testosterone regulation taking into account the presence of two types of testosterone hormones. Journal of Biological Systems. Vol.23, No.2 (2015), 259-273. doi:10.1142/S0218339015500138 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/35276
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Title
A model for the testosterone regulation taking into account the presence of two types of testosterone hormones
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Abstract
© 2015 World Scientific Publishing Company. The purpose of this paper is to study the effect of sex hormone binding globulin (SHBG) on the mathematical model of the hypothalamic-pituitary-gonadal (HPG) endocrine cycle which regulates the production of the male hormone testosterone. Large amounts of total circulating testosterone are bound to SHBG making them. Standard analytical techniques are used to analyze the modified mathematical model which includes a delay to account for the time required for luteinizing hormone emitted by the pituitary gland to reach the testis, to determine the steady state, its stability and the critical delay needed for the bifurcation. Numerical simulation of the solutions of the model is performed to illustrate the possible behaviors.