Publication: Vitamin D-enhanced duodenal calcium transport
Issued Date
2015-01-01
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ISSN
00836729
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2-s2.0-84938596846
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Mahidol University
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SCOPUS
Bibliographic Citation
Vitamins and Hormones. Vol.98, (2015), 407-440
Suggested Citation
Kannikar Wongdee, Narattaphol Charoenphandhu Vitamin D-enhanced duodenal calcium transport. Vitamins and Hormones. Vol.98, (2015), 407-440. doi:10.1016/bs.vh.2014.12.010 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/35568
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Title
Vitamin D-enhanced duodenal calcium transport
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Abstract
© 2015 Elsevier Inc. All rights reserved. For humans and rodents, duodenum is a very important site of calcium absorption since it is exposed to ionized calcium released from dietary complexes by gastric acid. Calcium traverses the duodenal epithelium via both transcellular and paracellular pathways in a vitamin D-dependent manner. After binding to the nuclear vitamin D receptor, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] upregulates the expression of several calcium transporter genes, e.g., TRPV5/6, calbindin-D9k, plasma membrane Ca2+-ATPase1b, and NCX1, thereby enhancing the transcellular calcium transport. This action has been reported to be under the regulation of parathyroid-kidney-intestinal and bone-kidney-intestinal axes, in which the plasma calcium and fibroblast growth factor-23 act as negative feedback regulators, respectively. 1,25(OH)2D3 also modulates the expression of tight junction-related genes and convective water flow, presumably to increase the paracellular calcium permeability and solvent drag-induced calcium transport. However, vitamin D-independent calcium absorption does exist and plays an important role in calcium homeostasis under certain conditions, particularly in neonatal period, pregnancy, and lactation as well as in naturally vitamin D-impoverished subterranean mammals.