Publication: Human norovirus genogroup II recombinants in Thailand, 2009–2014
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Issued Date
2015-10-30
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03048608
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2-s2.0-84942502923
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Mahidol University
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SCOPUS
Bibliographic Citation
Archives of Virology. Vol.160, No.10 (2015), 2603-2609
Suggested Citation
Tikumporn Phumpholsup, Thaweesak Chieochansin, Sompong Vongpunsawad, Viboonsuk Vuthitanachot, Sunchai Payungporn, Yong Poovorawan Human norovirus genogroup II recombinants in Thailand, 2009–2014. Archives of Virology. Vol.160, No.10 (2015), 2603-2609. doi:10.1007/s00705-015-2545-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/36057
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Title
Human norovirus genogroup II recombinants in Thailand, 2009–2014
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Abstract
© 2015, Springer-Verlag Wien. Norovirus (NoV) is a major cause of nonbacterial acute gastroenteritis worldwide. New strains emerge partly due to viral recombination. In Thailand, there is a lack of data on NoV recombinants among clinical isolates. We screened stool samples from pediatric diarrheal patients for norovirus by RT-PCR and found GII.4 to be the most prevalent genotype. Phylogenetic and SimPlot analyses detected seven intra-genogroup recombinant strains: three GII.21/GII.3, two GII.12/GII.3, and two GII.12/GII.1 recombinants. Maximum chi-square analysis indicated that all had similar breakpoints near the ORF1/ORF2 junction (p < 0.001), either slightly upstream within the C-terminus of RdRp or downstream within the N-terminal domain of VP1.