Publication: Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice
Issued Date
2015-04-08
Resource Type
ISSN
19346069
19313128
19313128
Other identifier(s)
2-s2.0-84927018652
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Cell Host and Microbe. Vol.17, No.4 (2015), 526-535
Suggested Citation
Sebastian A. Mikolajczak, Ashley M. Vaughan, Niwat Kangwanrangsan, Wanlapa Roobsoong, Matthew Fishbaugher, Narathatai Yimamnuaychok, Nastaran Rezakhani, Viswanathan Lakshmanan, Naresh Singh, Alexis Kaushansky, Nelly Camargo, Michael Baldwin, Scott E. Lindner, John H. Adams, Jetsumon Sattabongkot, Stefan H.I. Kappe Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice. Cell Host and Microbe. Vol.17, No.4 (2015), 526-535. doi:10.1016/j.chom.2015.02.011 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/36116
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Title
Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice
Author(s)
Sebastian A. Mikolajczak
Ashley M. Vaughan
Niwat Kangwanrangsan
Wanlapa Roobsoong
Matthew Fishbaugher
Narathatai Yimamnuaychok
Nastaran Rezakhani
Viswanathan Lakshmanan
Naresh Singh
Alexis Kaushansky
Nelly Camargo
Michael Baldwin
Scott E. Lindner
John H. Adams
Jetsumon Sattabongkot
Stefan H.I. Kappe
Ashley M. Vaughan
Niwat Kangwanrangsan
Wanlapa Roobsoong
Matthew Fishbaugher
Narathatai Yimamnuaychok
Nastaran Rezakhani
Viswanathan Lakshmanan
Naresh Singh
Alexis Kaushansky
Nelly Camargo
Michael Baldwin
Scott E. Lindner
John H. Adams
Jetsumon Sattabongkot
Stefan H.I. Kappe
Abstract
© 2015 Elsevier Inc. Plasmodium vivax malaria is characterized by periodic relapses of symptomatic blood stage parasite infections likely initiated by activation of dormant liver stage parasites-hypnozoites. The lack of tractable P. vivax animal models constitutes an obstacle in examining P. vivax liver stage infection and drug efficacy. To overcome this obstacle, we have used human liver-chimeric (huHep) FRG KO mice as a model for P. vivax infection. FRG KO huHep mice support P. vivax sporozoite infection, liver stage development, and hypnozoite formation. We show complete P. vivax liver stage development, including maturation into infectious exo-erythrocytic merozoites as well as the formation and persistence of hypnozoites. Prophylaxis or treatment with the antimalarial primaquine can prevent and eliminate liver stage infection, respectively. Thus, P. vivax-infected FRG KO huHep mice are a model to investigate liver stage development and dormancy and may facilitate the discovery of drugs targeting relapsing malaria.