Publication: Effects of artesunate treatment on Plasmodium gallinaceum transmission in the vectors Aedes aegypti and Culex quinquefasciatus
3
Issued Date
2015-01-01
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ISSN
18732550
03044017
03044017
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2-s2.0-84920453275
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Mahidol University
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SCOPUS
Bibliographic Citation
Veterinary Parasitology. Vol.207, No.1-2 (2015), 161-165
Suggested Citation
Mintra Pruck-Ngern, Sittiporn Pattaradilokrat, Kamlang Chumpolbanchorn, Suntorn Pimnon, Somphong Narkpinit, Pongchai Harnyuttanakorn, Prayute Buddhirakkul, Tawee Saiwichai Effects of artesunate treatment on Plasmodium gallinaceum transmission in the vectors Aedes aegypti and Culex quinquefasciatus. Veterinary Parasitology. Vol.207, No.1-2 (2015), 161-165. doi:10.1016/j.vetpar.2014.10.032 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/36137
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Title
Effects of artesunate treatment on Plasmodium gallinaceum transmission in the vectors Aedes aegypti and Culex quinquefasciatus
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Abstract
© 2014 Elsevier B.V. In the absence of vaccines, chemotherapy is an effective and economical way for controlling malaria. Development of anti-malarial drugs that target pathogenic blood stage parasites and gametocytes is preferable for the treatment as it can alleviate the host's morbidity and mortality and block transmission of the Plasmodium parasite. Recently, our laboratory has developed an in vivo transmission blocking assay that involves administration of 7 consecutive daily doses of a test compound into domestic chickens (. Gallus gallus domesticus) infected with the avian malaria parasite Plasmodium gallinaceum with 10% parasitaemia and 1% gametocytaemia. To compromise the cost and time for artesunate (ATN) treatment, this study aimed to investigate effects of a 5-day consecutive administration of 10 milligrams per kilogram (mg/kg) ATN on P. gallinaceum infection in chickens and transmission to two natural vectors, Aedes aegypti and Culex quinquefasciatus. Our study showed that the treatment with 10. mg/kg ATN for 7 days, but not 5 days, completely eliminated blood stage infections, prevented recrudescence and blocked gametocyte production and transmission of P. gallinaceum to its vectors, thereby confirming the potent schizontocidal and gametocytocidal activities of ATN. This regimen should be further evaluated in field trials.