Publication: Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand
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2015-08-01
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10986596
00664804
00664804
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2-s2.0-84939825761
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Mahidol University
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Antimicrobial Agents and Chemotherapy. Vol.59, No.8 (2015), 5080-5083
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Tiphaine Gaillard, Kanlaya Sriprawat, Sébastien Briolant, Chirapat Wangsing, Nathalie Wurtz, Meïli Baragatti, Morgane Lavina, Aurélie Pascual, François Nosten, Bruno Pradines (2015). Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/36370.
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Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand
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Institut de recherche biomedicale des armees
Unite de Recherche sur les Maladies Infectieuses et Tropicales emergentes
HIA Sainte-Anne a Toulon
Mahidol University
Direction Inter-Armées du Service de Santé
Institut Pasteur de la Guyane
Mathematiques informatiques et statistique pour l’environnement et l’agronomie (MISTEA)
Centre National de Référence du Paludisme
University of Oxford
Unite de Recherche sur les Maladies Infectieuses et Tropicales emergentes
HIA Sainte-Anne a Toulon
Mahidol University
Direction Inter-Armées du Service de Santé
Institut Pasteur de la Guyane
Mathematiques informatiques et statistique pour l’environnement et l’agronomie (MISTEA)
Centre National de Référence du Paludisme
University of Oxford
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Abstract
Copyright © 2015, American Society for Microbiology. All Rights Reserved. Determinations of doxycycline 50% inhibitory concentrations (IC50) for 620 isolates from northwest Thailand were performed via the isotopic method, and the data were analyzed by the Bayesian method and distributed into two populations (mean IC50s of 13.15 μM and 31.60 μM). There was no significant difference between the group with low IC50s versus the group with high IC50s with regard to copy numbers of the Plasmodium falciparum tetQ (pftetQ) gene (P = 0.11) or pfmdt gene (P = 0.87) or the number of PfTetQ KYNNNN repeats (P = 0.72).