Publication: Primary Cutaneous NK/T-cell lymphoma, nasal type and cd56-positive peripheral t-cell lymphoma A cellular lineage and clinicopathologic study of 60 patients from Asia
Issued Date
2015-01-20
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ISSN
15320979
01475185
01475185
Other identifier(s)
2-s2.0-84919352045
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Surgical Pathology. Vol.39, No.1 (2015), 1-12
Suggested Citation
Katsuyoshi Takata, Min Eui Hong, Panitta Sitthinamsuwan, Florence Loong, Soo Yong Tan, Jau Yu Liau, Pin Pen Hsieh, Siok Bian Ng, Sheau Fang Yang, Tawatchai Pongpruttipan, Sanya Sukpanichnant, Yok Lam Kwong, Young Hyeh Ko, Yung Tsu Cho, Wee Joo Chng, Takashi Matsushita, Tadashi Yoshino, Shih Sung Chuang Primary Cutaneous NK/T-cell lymphoma, nasal type and cd56-positive peripheral t-cell lymphoma A cellular lineage and clinicopathologic study of 60 patients from Asia. American Journal of Surgical Pathology. Vol.39, No.1 (2015), 1-12. doi:10.1097/PAS.0000000000000312 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/36526
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Title
Primary Cutaneous NK/T-cell lymphoma, nasal type and cd56-positive peripheral t-cell lymphoma A cellular lineage and clinicopathologic study of 60 patients from Asia
Other Contributor(s)
Okayama University Medical School
Kanazawa University School of Medicine
Samsung Medical Center
Samsung Medical Center, Sungkyunkwan University
Mahidol University
Departments of Pathology
Queen Mary Hospital Hong Kong
Singapore General Hospital
National University Health System
Cancer Science Institute of Singapore
National Taiwan University Hospital
Taipei Medical University
Veterans General Hospital-Kaohsiung Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kanazawa University School of Medicine
Samsung Medical Center
Samsung Medical Center, Sungkyunkwan University
Mahidol University
Departments of Pathology
Queen Mary Hospital Hong Kong
Singapore General Hospital
National University Health System
Cancer Science Institute of Singapore
National Taiwan University Hospital
Taipei Medical University
Veterans General Hospital-Kaohsiung Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital
Abstract
Copyright © 2014 by Lippincott Williams & Wilkins. Primary cutaneous, extranodal natural killer/T-cell lymphoma, nasal type (PC-ENKTL), is a rare Epstein-Barr virus (EBV)-associated neoplasm with poorly defined clinicopathologic features. We performed a multinational retrospective study of PC-ENKTL and CD56-positive EBVnegative peripheral T-cell lymphoma (PC-CD56+PTCL) in Asia in an attempt to elucidate their clinicopathologic features. Using immunohistochemistry for T-cell receptors (TCRs), in situ hybridization for EBV, and TCR gene rearrangement, we classified 60 tumors into 51 with PC-ENKTL (20 of NK-cell, 17 T-cell, and 14 indeterminate lineages) and 9 with PCCD56+ PTCL. Tumors of T-cell origin accounted for 46% of PC-ENKTLs with half of these cases being TCR-silent. As compared with T-lineage tumors, PC-ENKTLs of NK-cell lineage had more frequent involvement of regional lymph nodes and more frequently CD8-negative and CD56-positive. Cases of PC-ENKTL showed more frequent tumor necrosis, younger age, and a higher frequency of CD16 and CD30 expression than cases of PC-CD56+PTCL. CD56-positive T-lineage PCENKTL tumors (n=8) had more localized disease in the TNM (tumor-node-metastasis) staging and were more often of gd Tcell origin compared with cases of PC-CD56+PTCL (n=9). PC-ENKTLs and PC-CD56+PTCLs were equally aggressive, with a 5-year overall survival rate of 25%. Tumor necrosis and CD16 expression may serve as useful surrogates for differentiating PC-ENKTL from PC-CD56+PTCL. A single lesion, an elevated lactate dehydrogenase level, and the presence of B symptoms were independent poor prognostic factors for PCENKTL in multivariate analysis. Further studies with more cases are warranted to delineate the clinicopathologic features and significance of EBV in these rare lymphomas.