Publication: Antibacterial and antiproliferative activities of plumericin, an iridoid isolated from Momordica charantia vine
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Issued Date
2015-01-01
Resource Type
ISSN
17414288
1741427X
1741427X
Other identifier(s)
2-s2.0-84928539717
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Mahidol University
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SCOPUS
Bibliographic Citation
Evidence-based Complementary and Alternative Medicine. Vol.2015, (2015)
Suggested Citation
Jutamas Saengsai, Sumonthip Kongtunjanphuk, Nuttawan Yoswatthana, Tanawan Kummalue, Weena Jiratchariyakul Antibacterial and antiproliferative activities of plumericin, an iridoid isolated from Momordica charantia vine. Evidence-based Complementary and Alternative Medicine. Vol.2015, (2015). doi:10.1155/2015/823178 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/36831
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Title
Antibacterial and antiproliferative activities of plumericin, an iridoid isolated from Momordica charantia vine
Abstract
© 2015 Jutamas Saengsai et al. Plumericin, an iridoid lactone, was isolated with relatively high yield from Momordica charantia vine using the supercritical fluid extraction (SFE) and the separation box (Sepbox) comprising dual combination of high-performance liquid chromatography and solid phase extraction. This compound showed antibacterial activity against Enterococcus faecalis and Bacillus subtilis with minimum inhibitory concentration (MIC) values better than cloxacillin. Plumericin potently inhibited proliferation of two leukemic cancer cell lines: they were acute and chronic leukemic cancer cell lines, NB4 and K562, with the effective doses (ED of 4.35 ± 0.21 and 5.58 ± 0.35 μg/mL, respectively. In addition, the mechanism of growth inhibition in both cell lines was induced by apoptosis, together with G2/M arrest in K562 cells.