Publication: Plasma prefractionation methods for proteomic analysis and perspectives in clinical applications
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Issued Date
2017-07-01
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ISSN
18628354
18628346
18628346
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2-s2.0-85017227344
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Mahidol University
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SCOPUS
Bibliographic Citation
Proteomics - Clinical Applications. Vol.11, No.7-8 (2017)
Suggested Citation
Somchai Chutipongtanate, Supawat Chatchen, Jisnuson Svasti Plasma prefractionation methods for proteomic analysis and perspectives in clinical applications. Proteomics - Clinical Applications. Vol.11, No.7-8 (2017). doi:10.1002/prca.201600135 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/41852
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Title
Plasma prefractionation methods for proteomic analysis and perspectives in clinical applications
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Abstract
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Plasma is a rich source of biomarkers with clinical relevance. However, the wide dynamic range of protein concentration hinders the detection of low abundance proteins. Plasma prefractionation methods serve as indispensable tools to reduce plasma complexity, allowing the opportunity to explore tissue-derived proteins which leak into the circulation. This review summarizes common approaches in plasma prefractionation methods for proteomic analysis and then discusses some considerations in plasma prefractionation for clinical applications, reviewing some examples of its use in clinical situations.