Publication: A novel method for dengue virus detection and antibody screening using a graphene-polymer based electrochemical biosensor
Issued Date
2017-02-01
Resource Type
ISSN
15499642
15499634
15499634
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2-s2.0-85009895042
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Mahidol University
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SCOPUS
Bibliographic Citation
Nanomedicine: Nanotechnology, Biology, and Medicine. Vol.13, No.2 (2017), 549-557
Suggested Citation
Krongkaew Navakul, Chompunuch Warakulwit, Pa thai Yenchitsomanus, Aussara Panya, Peter A. Lieberzeit, Chak Sangma A novel method for dengue virus detection and antibody screening using a graphene-polymer based electrochemical biosensor. Nanomedicine: Nanotechnology, Biology, and Medicine. Vol.13, No.2 (2017), 549-557. doi:10.1016/j.nano.2016.08.009 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/42009
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Title
A novel method for dengue virus detection and antibody screening using a graphene-polymer based electrochemical biosensor
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Abstract
© 2016 Elsevier Inc. Dengue fever is a major disease that kills many people in the developing world every year. During early infection, a patient displays a high temperature without other signs. After this stage, and without proper treatment, serious damage to internal organs can happen, which occasionally leads to death. A rapid technique for the early detection of dengue virus (DENV) could reduce the number of fatalities. This study presents a new technique for the detection, classification and antibody screening of DENV based on electrochemical impedance spectroscopy (EIS). We found that the charge transfer resistance (Rct) of a gold electrode coated with graphene oxide reinforced polymer was influenced by virus type and quantity exposed on the surface. Molecular recognition capability established during the GO-polymer composite preparation was used to explain this observation. The linear dependence of Rctversus virus concentrations ranged from 1 to 2 × 103 pfu/mL DENV with a 0.12 pfu/mL detection limit.