Publication: Terpenoids with potent antimycobacterial activity against Mycobacterium tuberculosis from Trigonostemon reidioides roots
1
Issued Date
2017-01-01
Resource Type
ISSN
14645416
00404020
00404020
Other identifier(s)
2-s2.0-85012868787
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Tetrahedron. Vol.73, No.12 (2017), 1594-1601
Suggested Citation
Praphakorn Kaemchantuek, Ratchanaporn Chokchaisiri, Samran Prabpai, Palangpon Kongsaeree, Warangkana Chunglok, Tanyarath Utaipan, Walee Chamulitrat, Apichart Suksamrarn Terpenoids with potent antimycobacterial activity against Mycobacterium tuberculosis from Trigonostemon reidioides roots. Tetrahedron. Vol.73, No.12 (2017), 1594-1601. doi:10.1016/j.tet.2017.02.006 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/42056
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Terpenoids with potent antimycobacterial activity against Mycobacterium tuberculosis from Trigonostemon reidioides roots
Abstract
© 2017 Elsevier Ltd Phytochemical investigation of Trigonostemon reidioides roots led to the isolation of fourteen compounds. These included six new diterpenoids, trigonoreidons A−F (1−6), together with eight known diterpenoids 7−14. The structures of the new compounds were elucidated by spectroscopic techniques and the absolute configuration at the asymmetric carbon was determined by the modified Mosher's method. The structure of trigonoreidon B (2) was confirmed by X-ray crystallographic analysis. The known compounds were identified by comparison of the spectroscopic and physical data with those of reported values. The isolated compounds were evaluated for antimycobacterial activity against Mycobacterium tuberculosis. Among the compounds that exhibited antimycobacterial activity, the diterpenoids rediocide C (12) and rediocide G (14) were the most active compounds, with the MIC value of 3.84 μM.