Publication: Occurrence of the – –<sup>SEA</sup>, – –<sup>THAI</sup>and – –<sup>FIL</sup>α-Thalassemia-1 Carriers from a 7-Year Study at Ramathibodi Hospital, Bangkok, Thailand
Issued Date
2016-07-03
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1532432X
03630269
03630269
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2-s2.0-84982933523
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Mahidol University
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SCOPUS
Bibliographic Citation
Hemoglobin. Vol.40, No.4 (2016), 283-284
Suggested Citation
Kobkorn Pongjantharasatien, Wansa Banyatsuppasin, Sonnarong Pounsawat, Sumalee Jindadamrongwech Occurrence of the – –<sup>SEA</sup>, – –<sup>THAI</sup>and – –<sup>FIL</sup>α-Thalassemia-1 Carriers from a 7-Year Study at Ramathibodi Hospital, Bangkok, Thailand. Hemoglobin. Vol.40, No.4 (2016), 283-284. doi:10.1080/03630269.2016.1189932 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/42951
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Title
Occurrence of the – –<sup>SEA</sup>, – –<sup>THAI</sup>and – –<sup>FIL</sup>α-Thalassemia-1 Carriers from a 7-Year Study at Ramathibodi Hospital, Bangkok, Thailand
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Abstract
© 2016 Informa UK Limited, trading as Taylor & Francis Group. α-Thalassemia (α-thal) is one of the most common genetic diseases in Thailand. Homozygosity of α-thal-1 (– –/– –) and compound heterozygosity of α-thal-1/α-thal-2 (– –/–α) leads to Hb Bart's (γ4) hydrops fetalis and Hb H (β4) disease, respectively. In order to better control and provide prevention of α-thal disease, the prevalence of α-thal-1 carriers and the types of genotypes in the Thai population should be known. A 7-year retrospective study, employing multiplex gap-polymerase chain reaction (gap-PCR) of 31,632 blood samples from Ramathibodi Hospital, Mahidol University, Bangkok, revealed an α-thal-1 carrier rate of 14.40% with the – –SEA(NG_000006.1: g.26264_45564del19301), – –THAI(NG_000006.1: g.10664_44164del33501) and – –FIL(NG_000006.1: g.11684_43534del31851) genotypes, constituting frequencies of 14.21, 0.18 and 0.01%, respectively. Although the – –FILgenotype is rare in the Thailand, its detection should be included in future α-thal screening programs.