Publication: Paradoxical roles of cyclin D1 in DNA stability
6
Issued Date
2016-06-01
Resource Type
ISSN
15687856
15687864
15687864
Other identifier(s)
2-s2.0-84964878484
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Mahidol University
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SCOPUS
Bibliographic Citation
DNA Repair. Vol.42, (2016), 56-62
Suggested Citation
Siwanon Jirawatnotai, Gunya Sittithumcharee Paradoxical roles of cyclin D1 in DNA stability. DNA Repair. Vol.42, (2016), 56-62. doi:10.1016/j.dnarep.2016.04.011 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/43013
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Title
Paradoxical roles of cyclin D1 in DNA stability
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Abstract
© 2016 Elsevier B.V. Maintenance of DNA integrity is vital for all of the living organisms. Consequence of DNA damaging ranges from, introducing harmless synonymous mutations, to causing disease-associated mutations, genome instability, and cell death. A cell cycle protein cyclin D1 is an established cancer-driving protein. However, contribution of cyclin D1 to cancer formation and cancer survival is not entirely known. In cancer tissues, overexpression of cyclin D1 is associated with both cancer genome instability, and resistance to DNA-damaging cancer drugs. Emerging evidence indicated that cyclin D1 may play novel direct roles in regulating DNA repair. Here we provide an insight how cyclin D1 expression may contribute to DNA repair and chromosome instability, and how these functions may facilitate cancer formation, and drug resistance.