Publication: Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H266
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Issued Date
2016-01-01
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ISSN
18767753
18735061
18735061
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2-s2.0-84954117358
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Mahidol University
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SCOPUS
Bibliographic Citation
Stem Cell Research. Vol.16, No.1 (2016), 166-169
Suggested Citation
Adele G. Marthaler, Benjamin Schmid, Alisa Tubsuwan, Ulla B. Poulsen, Poul Hyttel, Troels T. Nielsen, Jørgen E. Nielsen, Bjørn Holst Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H266. Stem Cell Research. Vol.16, No.1 (2016), 166-169. doi:10.1016/j.scr.2015.12.029 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/43182
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Title
Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H266
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Abstract
© 2016. Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease primarily affecting the cerebellum. Very little is known about the molecular mechanisms underlying the disease and, to date, no cure or treatment is available. Here, we demonstrate the generation of an induced pluripotent stem cell (iPSC) line of a SCA2 patient. The selected clone has been proven to be a bona fide iPSC line, which retains a normal karyotype. Due to its differentiation potential into neurons, this iPSC line will be a valuable tool in studying a disease-specific phenotype of SCA2.