Publication: In vitro controlled release of clove essential oil in self-assembly of amphiphilic polyethylene glycol-block-polycaprolactone
7
Issued Date
2016-04-02
Resource Type
ISSN
14645246
02652048
02652048
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2-s2.0-84961149423
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Microencapsulation. Vol.33, No.3 (2016), 239-248
Suggested Citation
O. Thonggoom, N. Punrattanasin, N. Srisawang, N. Promawan, R. Thonggoom In vitro controlled release of clove essential oil in self-assembly of amphiphilic polyethylene glycol-block-polycaprolactone. Journal of Microencapsulation. Vol.33, No.3 (2016), 239-248. doi:10.3109/02652048.2016.1156173 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/43379
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Title
In vitro controlled release of clove essential oil in self-assembly of amphiphilic polyethylene glycol-block-polycaprolactone
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Abstract
© 2016 Informa UK Limited, trading as Taylor & Francis Group. In this study, a micellar delivery system with an amphiphilic diblock copolymer of poly (ethylene glycol) and poly (ɛ-caprolactone) was synthesised and used to incorporate hydrophobic clove essential oil (CEO). To determine an optimal delivery system, the effects of the copolymer’s hydrophobic block length and the CEO-loading content on the encapsulation of CEO were investigated. Percentages of entrapment efficiency (%EE), CEO loading (%CEO), and in vitro release profiles were determined. The size, size distribution, zeta potential, and morphology of the obtained micelles were determined by DLS, FE-SEM, and TEM. The %EE, %CEO, and in vitro release profiles of CEO incorporated in micelles were analysed by HPLC. The study revealed a sustained release profile of CEO from CEO-loaded micelles. The results indicate the successful formulation of CEO-loaded PEG-b-PCL micelle nanoparticles. It is suggested that this micelle system has considerably potential applications in the sustained release of CEO in intravascular drug delivery.