Publication: Inhaled nebulized sodium nitrite decreases pulmonary artery pressure in β-thalassemia patients with pulmonary hypertension
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Issued Date
2018-06-01
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10898611
10898603
10898603
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2-s2.0-85030634045
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Mahidol University
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SCOPUS
Bibliographic Citation
Nitric Oxide - Biology and Chemistry. Vol.76, (2018), 174-178
Suggested Citation
Teerapat Yingchoncharoen, Teewin Rakyhao, Suporn Chuncharunee, Piyamitr Sritara, Pavit Pienvichit, Kittiphong Paiboonsukwong, Piyadon Sathavorasmith, Kanjana Sirirat, Thanaporn Sriwantana, Sirada Srihirun, Nathawut Sibmooh Inhaled nebulized sodium nitrite decreases pulmonary artery pressure in β-thalassemia patients with pulmonary hypertension. Nitric Oxide - Biology and Chemistry. Vol.76, (2018), 174-178. doi:10.1016/j.niox.2017.09.010 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/45140
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Title
Inhaled nebulized sodium nitrite decreases pulmonary artery pressure in β-thalassemia patients with pulmonary hypertension
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Abstract
© 2017 Elsevier Inc. Pulmonary hypertension is a life-threatening complication in β-thalassemia. Inhaled sodium nitrite has vasodilatory effect on pulmonary vasculature. However, its effect on pulmonary artery pressure (PAP) in β-thalassemia subjects with pulmonary hypertension has never been reported. In this study, we investigated the change in PAP during inhalation of sodium nitrite in 5 β-thalassemia patients. We demonstrated that sodium nitrite administered by nebulization rapidly decreased PAP as measured by echocardiography and right heart catheterization. The effect of nitrite was short as PAP returned to baseline at end of inhalation. Our findings support acute pulmonary vasodilation effect of nitrite in β-thalassemia with pulmonary hypertension.