Publication: The immunology of Zika Virus
Issued Date
2018-01-01
Resource Type
ISSN
1759796X
20461402
20461402
Other identifier(s)
2-s2.0-85042523335
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Mahidol University
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SCOPUS
Bibliographic Citation
F1000Research. Vol.7, (2018)
Suggested Citation
Gavin Screaton, Abigail Culshaw, Juthathip Mongkolsapaya The immunology of Zika Virus. F1000Research. Vol.7, (2018). doi:10.12688/f1000research.12271.1 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/45327
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Title
The immunology of Zika Virus
Abstract
© 2018 Culshaw A et al. Zika virus (ZIKV) was initially thought to cause only mild, self-limiting symptoms. However, recent outbreaks have been associated with the autoimmune disease Guillain-Barré syndrome and causally linked to a congenital malformation known as microcephaly. This has led to an urgent need for a safe and effective vaccine. A comprehensive understanding of the immunology of ZIKV infection is required to aid in the design of such a vaccine. Whilst details of both innate and adaptive immune responses to ZIKV are emerging, further research is needed. As immunopathogenesis has been implicated in poor outcomes following infection with the related dengue virus, identification of cross-reactive immune responses between flaviviruses and the impact they may have on disease progression is also of high importance.