Publication: Synthesis and investigations of mineral ions-loaded apatite from fish scale and PLA/chitosan composite for bone scaffolds
Issued Date
2018-06-15
Resource Type
ISSN
18734979
0167577X
0167577X
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2-s2.0-85044130494
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Mahidol University
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SCOPUS
Bibliographic Citation
Materials Letters. Vol.221, (2018), 143-146
Suggested Citation
Weeraphat Pon-On, Panan Suntornsaratoon, Narattaphol Charoenphandhu, Jirawan Thongbunchoo, Nateetip Krishnamra, I. Ming Tang Synthesis and investigations of mineral ions-loaded apatite from fish scale and PLA/chitosan composite for bone scaffolds. Materials Letters. Vol.221, (2018), 143-146. doi:10.1016/j.matlet.2018.03.063 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/45804
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Title
Synthesis and investigations of mineral ions-loaded apatite from fish scale and PLA/chitosan composite for bone scaffolds
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Abstract
© 2018 In this study, composite scaffolds consisting of mineral ion-loaded hydroxyapatite derived from fish scale (mHAFS) in a poly(lactic acid) (PLA)/chitosan (Chi) matrix (mHAFS@PLAChi) were fabricated by an in situ blending technique. Mineral ion loaded HAFS was successfully converted into mHAFS via the hydrothermal heating of HAFS in a SBF (simulated body fluid) solution. The composite mHAFS with PLAChi showed a compressive strength of 20 MPa and a compressive modulus of 539.88 MPa with a microporous structure. In vitro investigation showed that the UMR-106 cells adhered well and proliferated on the mHAFS@PLAChi surface. Most importantly it improved the cell viability and alkaline phosphate (ALP) activity. These findings suggest that these synthesized materials have great potential for use in bone tissue engineering.