Publication: A cohort study of prognostic factors associated with recurrence or metastasis of gastrointestinal stromal tumor (GIST) of stomach
2
Issued Date
2018-11-01
Resource Type
ISSN
20490801
Other identifier(s)
2-s2.0-85053492178
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Annals of Medicine and Surgery. Vol.35, (2018), 1-5
Suggested Citation
Chairat Supsamutchai, Chumpon Wilasrusmee, Pitichote Hiranyatheb, Jakrapan Jirasiritham, Teerawut Rakchob, Pattawia Choikrua A cohort study of prognostic factors associated with recurrence or metastasis of gastrointestinal stromal tumor (GIST) of stomach. Annals of Medicine and Surgery. Vol.35, (2018), 1-5. doi:10.1016/j.amsu.2018.08.010 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/46198
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
A cohort study of prognostic factors associated with recurrence or metastasis of gastrointestinal stromal tumor (GIST) of stomach
Other Contributor(s)
Abstract
© 2018 The Authors Background: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. The major risk factors of recurrence and metastasis are mitotic index and tumor size. This study investigates the risk of recurrence and metastasis in solely gastric GIST. The primary outcome is to evaluate risk of recurrence and metastasis. The secondary outcome is to analyse survival rates of patients who have recurrence and metastasis after curative resection. Method: A cohort of patients who underwent curative resection of gastric GIST between January 2006 to December 2016 was reviewed. The diagnosis was confirmed with positive CD34, DOG1 or KIT (CD117) immunohistochemistry. Risk factors of recurrence and metastasis were analyzed. Results: Sixty-eight patients who received curative resection and diagnosed as gastric GIST were included in this study. Twenty (29.41%) had recurrence or metastasis. The median follow up time was 31.95 months. The mostcommon type of surgery was partial gastric resection. There were statistically-significant differences between mitotic index 6 HPF or 6 HPF in tumor size 0-5 cm, 5-10 cm and 10 cm and the risk of recurrence or metastasis (p-value 0.036). In tumors sized 6-10 cm, patients with mitotic index 6 HPF had longer survival than patients with mitotic index 6 HPF (p-value 0.0147). Conclusion: The factor that determines the outcome of recurrence or metastasis in solely gastric GIST is high mitotic index count. Patients who have abdominal pain may be suspected as advanced disease. The type of operation and tumor size are not associated with recurrence or metastasis.