Publication: The teratogenic effects of glyphosate based herbicide (GBH) on the development of chick embryos
Submitted Date
Received Date
Accepted Date
Issued Date
2018-09-01
Copyright Date
Announcement No.
Application No.
Patent No.
Valid Date
Resource Type
Edition
Resource Version
Language
File Type
No. of Pages/File Size
ISBN
ISSN
22288082
eISSN
Scopus ID
WOS ID
Pubmed ID
arXiv ID
Call No.
Other identifier(s)
2-s2.0-85057550754
Journal Title
Volume
Issue
item.page.oaire.edition
Start Page
End Page
Access Rights
Access Status
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Physical Location
Bibliographic Citation
Siriraj Medical Journal. Vol.70, No.5 (2018), 419-428
Citation
Jantima Roongruangchai, Yadaridee Viravud, Vasana Plakornkul, Kesorn Sripaoraya, Naruemol Vijitsombat, Kosol Roongruangchai (2018). The teratogenic effects of glyphosate based herbicide (GBH) on the development of chick embryos. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/46358.
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
The teratogenic effects of glyphosate based herbicide (GBH) on the development of chick embryos
Alternative Title(s)
Author's Affiliation
Author's E-mail
Editor(s)
Editor's Affiliation
Corresponding Author(s)
Creator(s)
Compiler
Advisor(s)
Illustrator(s)
Applicant(s)
Inventor(s)
Issuer
Assignee
Other Contributor(s)
Series
Has Part
Abstract
© 2018 Siriraj Medical Journal. Objective: This study was conducted to investigate the teratogenic effects of GBH by using chick embryo as an animal model. Methods: The equal volume of 0.1 ml of 0.01%, 0.05%, 0.3%, and 0.5% w/v glyphosate solution were injected into yolk sacs of fertilized White Leghorn eggs at 21 h of incubation and repeated at the volume of 0.05 ml on the 3rd day of incubation. The embryos were observed for abnormalities on day 3, 6 and 10 of incubation. Results: The results showed that the mortality percentages increased as the concentration of glyphosate increased. Day 3 chick embryos showed retardation of development and several abnormalities, for instance, the irregular shape of the brain vesicles with an opening of anterior neuropore, small eye primordia with the optic cup and lens vesicle retardation, looser of the heart looping with dilated lumen, lesser number of branchial arches, absent of limb bud or tail fold. Day 6 chick embryos showed severe retardation of several organs. Microphthalmia, anophthalmia, ectopia cordis and ectopic viscerae were observed in day 6 chick embryos. On day 10, most embryos died earlier and living embryos showed normal external features but delayed ossifications which were significantly different from the control (P < 0.05). Conclusion: Glyphosate was toxic to chick embryos which directly caused mortality and was also a powerful teratogen which caused growth retardation and malformations on day 3 and day 6 and skeletal alteration on day. The effects were predicted to occur in other embryos including humans. Pregnant women should avoid contamination with GBH especially in the first trimester of pregnancy.