Publication: Serum interleukin 6 and cancer antigen 125 in the non-invasive diagnosis of endometriosis
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Issued Date
2018-06-01
Resource Type
ISSN
22840273
22840265
22840265
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2-s2.0-85051204413
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Endometriosis and Pelvic Pain Disorders. Vol.10, No.2 (2018), 116-122
Suggested Citation
Prasong Tanmahasamut, Ratthiporn Preukthanathorn, Chongdee Dangrat Serum interleukin 6 and cancer antigen 125 in the non-invasive diagnosis of endometriosis. Journal of Endometriosis and Pelvic Pain Disorders. Vol.10, No.2 (2018), 116-122. doi:10.1177/2284026518779861 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/46602
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Title
Serum interleukin 6 and cancer antigen 125 in the non-invasive diagnosis of endometriosis
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Abstract
© The Author(s) 2018. Background: The role of interleukin 6 in endometriosis has been extensively studied but results were inconsistent. The purpose of this study was to determine the performance of serum interleukin 6 and serum cancer antigen 125 for non-invasive diagnosis of endometriosis. Methods: In this prospective diagnostic study, 100 reproductive women who underwent laparoscopy were studies. Patients were divided into endometriosis group (n = 60) and control group (n = 40). Blood samples were taken preoperatively for analysis of serum interleukin 6 and cancer antigen 125 levels. Results: Level of serum interleukin 6 and cancer antigen 125 in endometriosis group were significantly higher than those in control group (1.93 versus <1.50 pg/mL and 41.85 versus 11.86 IU/mL, respectively). A cutoff level of interleukin 6 at 1.52 pg/mL provided sensitivity of 63.3%, specificity of 55%, positive predictive value of 67.9%, and negative predictive value of 50%. The threshold level of cancer antigen 125 at 31 IU/mL had sensitivity of 70%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 69%. The combined test had sensitivity of 86.7%, specificity of 60%, positive predictive value of 76.5%, and negative predictive value of 75%. The area under receiver operating characteristic curve of serum interleukin 6, cancer antigen 125, and combined test were 0.614, 0.945, and 0.945, respectively. Conclusion: Serum interleukin 6 is not suitable to be a candidate of serum marker for the diagnosis of endometriosis. Serum cancer antigen 125 is better than interleukin 6 for detection of endometriosis stage III/IV. Both of them had low performance for diagnostic test in minimal to mild endometriosis. The combined test does not add more benefit than using cancer antigen 125 alone.