Publication: Association between smoking and risk of primary sclerosing cholangitis: A systematic review and meta-analysis
Issued Date
2018-05-01
Resource Type
ISSN
20506414
20506406
20506406
Other identifier(s)
2-s2.0-85042462298
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
United European Gastroenterology Journal. Vol.6, No.4 (2018), 500-508
Suggested Citation
Karn Wijarnpreecha, Panadeekarn Panjawatanan, Omar Y. Mousa, Wisit Cheungpasitporn, Surakit Pungpapong, Patompong Ungprasert Association between smoking and risk of primary sclerosing cholangitis: A systematic review and meta-analysis. United European Gastroenterology Journal. Vol.6, No.4 (2018), 500-508. doi:10.1177/2050640618761703 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/46727
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Title
Association between smoking and risk of primary sclerosing cholangitis: A systematic review and meta-analysis
Abstract
© 2018, © Author(s) 2018. Background/Objectives: Studies have suggested that smokers may have a lower risk of primary sclerosing cholangitis (PSC) although the results have been inconsistent. This systematic review and meta-analysis was conducted to summarize all available data to better characterize this association. Methods: A comprehensive literature review was conducted using Medline and Embase databases through January 2018 to identify all studies that compared the risk of PSC among current/former smokers versus nonsmokers. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird. Results: Seven case-control studies with 2,307,393 participants met the eligibility criteria and were included in the meta-analysis. The risk of PSC among current smokers and former smokers was significantly lower than nonsmokers with the pooled odds ratio of 0.31 (95% CI, 0.18–0.53) and 0.52 (95% CI, 0.44–0.61), respectively. The risk remained significantly lower among current smokers and former smokers compared with nonsmokers even when only patients with PSC without inflammatory bowel disease were included. Conclusions: A significantly decreased risk of PSC among current and former smokers was demonstrated in this study.