Publication:
Prognostic factors for TB-associated uveitis in the Asia-Pacific Region: results of a modified Delphi survey

5

Issued Date

2020-01-01

Resource Type

Article

ISSN

14765454
0950222X

DOI

10.1038/s41433-019-0743-1

Other identifier(s)

2-s2.0-85077338289

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Mahidol University

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SCOPUS

Bibliographic Citation

Eye (Basingstoke). (2020)

Suggested Citation

Soumyava Basu, Rina La Distia Nora, Narsing A. Rao, Xuejuan Jiang, Ahmad Fuady, Peter J. McCluskey, Justine R. Smith, Soumyava Basu, Jyotirmay Biswas, Padmamalini Mahendradas, Salil Mehta, Kalpana Babu Murthy, Lukman Edwar, Kazuichi Murayama, Shelina Oli Mohamed, May Z.A. Win, Jessica Marie Abaño, Soon Phaik Chee, Shwu Jiuan Sheu, Somsiri Sukavatcharin, Narsing A. Rao Prognostic factors for TB-associated uveitis in the Asia-Pacific Region: results of a modified Delphi survey. Eye (Basingstoke). (2020). doi:10.1038/s41433-019-0743-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/49677

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Title

Prognostic factors for TB-associated uveitis in the Asia-Pacific Region: results of a modified Delphi survey

Author(s)

Soumyava Basu
 Rina La Distia Nora
 Narsing A. Rao
 Xuejuan Jiang
 Ahmad Fuady
 Peter J. McCluskey
 Justine R. Smith
 Soumyava Basu
 Jyotirmay Biswas
 Padmamalini Mahendradas
 Salil Mehta
 Kalpana Babu Murthy
 Lukman Edwar
 Kazuichi Murayama
 Shelina Oli Mohamed
 May Z.A. Win
 Jessica Marie Abaño
 Soon Phaik Chee
 Shwu Jiuan Sheu
 Somsiri Sukavatcharin
 Narsing A. Rao

Other Contributor(s)

De La Salle Health Sciences Institute
 Lilavati Hospital & Research Centre, Mumbai
 Kaohsiung Medical University Chung-Ho Memorial Hospital
 University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
 Universitas Indonesia
 Yong Loo Lin School of Medicine
 Sankara Nethralaya
 Osaka University
 Flinders University
 L.V. Prasad Eye Institute India
 Faculty of Medicine, Ramathibodi Hospital, Mahidol University
 Keck School of Medicine of USC
 Save Sight Institute
 Uveitis and Ocular Immunology Department
 Vittala International Institute of Ophthalmology and Prabha Eye Clinic and Research Centre
 University of Medicine 1
 Hospital Shah Alam

Abstract

© 2020, The Author(s), under exclusive licence to The Royal College of Ophthalmologists. Background: Prognostic factors for TB-associated uveitis (TBU) remain mostly unknown, due to the challenges in interpretation of patient data. We present consensus list of prognostic factors for resolution of inflammation in TBU, by experts across the Asia-Pacific region. Methods: We applied a modified Delphi technique to generate consensus on prognostic factors influencing the resolution of inflammation in TB-associated: anterior uveitis (AU), retinal vasculitis (RV), and multifocal serpiginoid choroiditis (MSC). The initial questionnaire was developed through a face-to-face meeting. Sixteen uveitis experts from eleven Asia-Pacific countries were included. A single investigator circulated the questionnaire electronically and received the responses. Participants scored each item on 4-point Likert scale, in three successive rounds. After each round, a number of items were reduced based on response, and summary of responses was provided to participants. At the end of Round 3, items were considered significant if they: (1) achieved a median ≥2, and interquartile range ≤1, and (2) ≥75% of the respondents agreed on whether the item was a positive or negative prognostic factor. Results: Forty-two putative questionnaire items were considered. At the end of Rounds 3, 4, 9, and 8 items in AU, RV, and MSC, respectively, met significance criteria. These included duration of disease, previous corticosteroid/immunosuppressive therapy, co-existent HIV, disease-specific imaging features, multidrug resistant TB, and duration of anti-TB therapy. Conclusions: Consensus were achieved on multiple ocular and systemic factors that influence resolution of inflammation in TBU. These will form the groundwork for validation in prospective clinical trials.

Keyword(s)

Medicine
 Neuroscience

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URI

https://repository.li.mahidol.ac.th/handle/123456789/49677

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Scopus 2020