Publication: Exhaustive exercise decreases renal organic anion transporter 3 function
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Issued Date
2019-03-01
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18806546
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2-s2.0-85054507491
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Physiological Sciences. Vol.69, No.2 (2019), 245-251
Suggested Citation
Tipwadee Bunprajun, Chaowalit Yuajit, Rattikarn Noitem, Varanuj Chatsudthipong Exhaustive exercise decreases renal organic anion transporter 3 function. Journal of Physiological Sciences. Vol.69, No.2 (2019), 245-251. doi:10.1007/s12576-018-0641-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/50236
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Title
Exhaustive exercise decreases renal organic anion transporter 3 function
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Abstract
© 2018, The Physiological Society of Japan and Springer Japan KK, part of Springer Nature. This study aimed to investigate the effects of various types of exercise on organic anion transporter 3 (Oat3) function, a major transporter that plays a role in the secretion of a variety of drugs and endogenous compounds. Male Wistar rats were randomly allocated to non-exercise, exhaustive, acute and training exercise groups. The function of Oat3 was assessed by the uptake of [ 3 H]-estrone sulfate ([ 3 H]-ES) into rat renal cortical slices. Acute and training exercises had no effect on [ 3 H]-ES uptake whereas a marked reduction in [ 3 H]-ES uptake occurred immediately after exhaustive exercise. However, the reduction in Oat3 function was gradually recovered at 6 and 24 h after the exercise session. Importantly, the impairment of Oat3 function was associated with a decrease in renal Oat3 protein expression. Our results indicate that exhaustive exercise produces a significant impact on renal organic anion transport function, which in turn could alter the plasma level of drugs and compounds in the body.