Publication: Expression and localization of VIAAT in distal uriniferous tubular epithelium of mouse
2
Issued Date
2019-03-01
Resource Type
ISSN
16180402
09409602
09409602
Other identifier(s)
2-s2.0-85056748592
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Mahidol University
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SCOPUS
Bibliographic Citation
Annals of Anatomy. Vol.222, (2019), 21-27
Suggested Citation
Waraporn Sakaew, Apussara Tachow, Wipawee Thoungseabyoun, Suthankamon Khrongyut, Atsara Rawangwong, Yada Polsan, Watanabe Masahiko, Hisatake Kondo, Wiphawi Hipkaeo Expression and localization of VIAAT in distal uriniferous tubular epithelium of mouse. Annals of Anatomy. Vol.222, (2019), 21-27. doi:10.1016/j.aanat.2018.11.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/50247
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Title
Expression and localization of VIAAT in distal uriniferous tubular epithelium of mouse
Abstract
© 2018 Elsevier GmbH Vesicular inhibitory amino acid transporter (VIAAT) is a transmembrane transporter which is responsible for the storage of gamma-aminobutyric acid (GABA) or glycine in synaptic vesicles. According to recent studies, GABA is known to be expressed in the kidney. For clear understanding of the intra-renal GABA signaling, the localization of VIAAT was examined in the present study. Intense immunoreactivity was found largely confined to the distal tubule epithelia, especially distinct in the inner medulla, although the immunoreactivity was discerned more or less in all tubules and glomeruli. No distinct immunoreactivity was seen in capillary endothelia or interstitial fibroblasts. In immuno-DAB and immuno-gold electron microscopy, the immunoreaction was found at the basal infoldings of plasma membranes and basal portions of the lateral plasma membranes, but not in any vesicles or vacuoles within the distal tubular cells. The significance of the enigmatic finding, localization of a vesicular molecule on selected portions of the plasma membrane of distal tubular cells, was discussed in view of the possibility of paracrine or autocrine effects of GABA on some other uriniferous tubular cells or interstitial cells.