Publication: Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice
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Issued Date
2019-02-05
Resource Type
ISSN
22111247
Other identifier(s)
2-s2.0-85060452019
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Mahidol University
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SCOPUS
Bibliographic Citation
Cell Reports. Vol.26, No.6 (2019), 1585-1597.e4
Suggested Citation
Vanessa Salazar, Brett W. Jagger, Juthathip Mongkolsapaya, Katherine E. Burgomaster, Wanwisa Dejnirattisai, Emma S. Winkler, Estefania Fernandez, Christopher A. Nelson, Daved H. Fremont, Theodore C. Pierson, James E. Crowe, Gavin R. Screaton, Michael S. Diamond Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice. Cell Reports. Vol.26, No.6 (2019), 1585-1597.e4. doi:10.1016/j.celrep.2019.01.052 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/50260
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Title
Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice
Abstract
© 2019 The Author(s) Salazar et al. show that SPOV, the flavivirus most closely related to ZIKV, infects mice when type I interferon signaling is blocked. SPOV causes ankle swelling and infection in the foot, which is more typical of alphaviruses. Human antibodies from ZIKV or DENV subjects protect against lethal SPOV challenge.